2008 International Conference on Frontiers of Dental and Craniofacial Research

CURRICULUM VITAE

NAME

Rulang Jiang

CORRESPONDENT

Center for Oral Biology and Department of Biomedical Genetics
University of Rochester School of Medicine and Dentistry
601 Elmwood Avenue, Box 611, Rochester, New York 14642, USA
Email: Rulang_Jiang@urmc.rochester.edu

EDUCATION

1984 1987 1995	B. S., Biology, Nanjing Normal University, Nanjing, China M. S., Genetics, Chinese Academy of Sciences, Beijing, China PhD, Biology, Wesleyan University, Middletown, Connecticut
RESEARCH AND/OR PROFESSIONAL EXPERIENCE
1984–1987 1987–1988 1989–1994 1994–1995 1995–1998 1999–2004 1999–2004 2002–2004 2004– 2005–	M. S. Thesis Research, Institute of Genetics, Chinese Academy of Sciences Research Scientist, Institute of Genetics, Chinese Academy of Sciences PhD candidates, Biology Department, Wesleyan University Postdoctoral Associate, Roche Institute of Molecular Biology, Nutley, New Jersey NIH Postdoctoral Fellows, the Jackson Laboratory, Bar Harbor, Maine Assistant Professor, Center for Oral Biology, University of Rochester Assistant Professor, Department of Biology, University of Rochester Assistant Professor, Department of Biomedical Genetics, University of Rochester Associate Professor, Eastman Department of Dentistry, University of Rochester Associate Professor, Department of Biology, University of Rochester
HONORS AND AWARDS
1991 1994 1994-1995 1997-1998 2000-2002	Arthur Klorfein Fund Scholarship Sigma Xi Student Research Award Roche Postdoctoral Fellowship NIH Individual NRSA Postdoctoral Fellowship Basil O'Connor Starter Scholar, March of Dimes Birth Defect Foundation
TEACHING EXPERIENCE
1999 2000 2001 2002 2003 2003 2004 2004 2005 2005 2005 2006 2006 2007	BIO228L, Laboratory of Cell and Developmental Biology IO407/GEN507, Advanced Genetics IO516, Current Topics in Developmental Genetics (Course Director) BIO228L, Laboratory of Cell and Developmental Biology BIO437, Advanced Developmental Biology (Course Director) ORB558, Craniofacial Growth and Development GEN508, Genes, Development and Disease (Course Director) GEN507, Advanced Genetics (Mouse Genetics section) GEN508, Genes, Development and Disease (Course Director) GEN507, Advanced Genetics (Mouse Genetics section) GEN508, Genes, Development and Disease (Course Director) GEN507, Advanced Genetics (Mouse Genetics section) ORB558, Craniofacial Growth and Development GEN508, Genes, Development and Disease (Course Director) GEN507, Advanced Genetics (Mouse Genetics section) ORB558, Craniofacial Growth and Development

PUBLICATIONS
1.	Jiang, R., and Liang, H. (1989). Biological effects of high- and low-energy laser irradiation. In: Application of Lasers in Biology and Medicine (ed. J. Li and H. Liang), pp. 35-41. Science Press, Beijing.
2.	Jiang, R., and Liang, H. (1989). Mitotic reversion in prophase of PTK1 cells induced by argon laser microirradiation. Cell Biophysics 14:271-282.
3.	Jiang, R., Lu, Z., and Liang, H. (1989). Use of laser microbeam irradiation as a tool in the characterization of chromosome structure and function. In: Application of Lasers in Biology and Medicine (ed. J. Li and H. Liang), pp. 189-210. Science Press, Beijing.
4.	Jiang, R., and Liang, H. (1991). A comparative study of cell killing effects of HPD plus laser irradiation on HeLa cells of different cell cycle stages. Chinese Journal of Lasers 18:316-320.
5.	Jiang, R., and Grabel, L.B. (1995). Function and differential expression of α6 integrin isoforms during parietal endoderm differentiation. Experimental Cell Research 217:195-204.
6.	Jiang, R., Kato, M., Bernfield, M., and Grabel, L.B. (1995). Expression of syndecan-1 changes during the differentiation of visceral and parietal endoderm from murine F9 teratocarcinoma cells. Differentiation 59:225-233.
7.	Jiang, R., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., and Gridley, T. (1997). Genomic organization and chromosomal localization of the mouse Snail (Sna) gene. Mammalian Genome 8:686-688.
8.	Jiang, R., and Gridley, T. (1997). Gene targeting: Things go better with Cre. Current Biology 7:R321-323.
9.	Lan, Y., Jiang, R., Shawber, C., Weinmaster, G., and Gridley, T. (1997). The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations. Mammalian Genome 8:875-876.
10.	Bell, S., Lan, Y., Jiang, R., and Gridley, T. (1998). Exclusion of Jagged2 as a candidate for the legless gene. Mammalian Genome 9:778-779.
11.	Jiang, R., Norton, C.R., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., and Gridley, T. (1998). Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene. Biochemica et Biophysica Acta 1443:251-254.
12.	Jiang, R., Lan, Y., Chapman, H.D., Shawber, C., Norton, C.R., Serreze, D.V., Weinmaster, G., and Gridley, T. (1998). Defects in limb, craniofacial and thymic development in Jagged2 mutant mice. Genes & Development 12:1046-1057.
13.	Jiang, R., Lan, Y., Norton, C.R., and Gridley, T. (1998). The Slug gene is not essential for mesoderm or neural crest development in mice. Developmental Biology 198:277-285.
14.	Lanford, P.J., Lan, Y., Jiang, R., Lindsell, C., Weinmaster, G., Gridley, T., and Kelley, M.W. (1999). Notch signaling mediates Hair cell development in mammalian cochlea. Nature Genetics 21:289-292.
15.	McCright, B., Gao, X., Lozier, J., Lan, Y., Shen, L., Maguire, M., Herzlinger, D., Weinmaster, G., Jiang, R., and Gridley, T. (2001). Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development 128:491-502.
16.	Lan, Y., Kingsley, P. D., Cho, E. S., and Jiang, R. (2001). Osr2, a new mouse gene related to Drosophila odd-skipped exhibits dynamic expression patterns during craniofacial, limb, and kidney development. Mechanisms of Development 107:175-179.
17.	Carver, E. A., Jiang, R., Lan, Y., Oram, K. F., and Gridley, T. (2001). The mouse Snail gene encodes a key regulator of the epithelial-mesenchymal transition. Molecular and Cellular Biology 21:8184-8188. (*Co-first authors)
18.	Bush, J. O., Lan, Y., Maltby, K. M., and Jiang, R. (2002). Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human Xlinked cleft palate gene. Developmental Dynamics 225:322-326.
19.	Krebs, L. T., Iwai, N., Nonaka, S., Welsh, I. C., Lan, Y., Jiang, R., Saijoh, Y., O’Brien, T. P., Hamada, H., and Gridley, T. (2003). Notch signaling regulates leftright asymmetry determination by inducing Nodal expression. Genes & Development 17:1207-1212.
20.	Bush, J. O., Maltby, K. M., Cho, E.-S., and Jiang, R. (2003). The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. Gene Expression Patterns (Mechanisms of Development) 3:533-538.
21.	Lan, Y., Ovitt, C. E., Cho, E.-S., Maltby, K. M., Wang, Q., and Jiang, R. (2004). Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development 131:3207-3216.
22.	Bush, J. O., Lan, Y., and Jiang, R. (2004). The cleft lip and palate defects in the Dancer mutant mice result from gain of function of the Tbx10 gene. Proceedings of the National Academy of Sciences USA 101:7022-7027.
23.	Hadland, B. K., Huppert, S., Kanungo, J., Xue, Y., Jiang, R., Gridley, T., Colon, R. A., Cheng, A. M., Kopan, R. and Longmore, G. D. (2004). A requirement for Notch1 distinguishes two phases of definitive hematopoiesis during development. Blood 104:3097-3105.
24.	Alappat, S. R., Zhang, Z., Suzuki, K., Zhang, X., Jiang, R., Yamada, G. and Chen, Y. (2005). The cellular and molecular etiology of cleft secondary palate in Fgf10 mutant mice. Developmental Biology 277:102-113.
25.	Knight, A. S., Schutte, B. C., Jiang, R. and Dixon, M. J. (2005). Developmental expression analysis of the mouse and chick orthologues of IRF6: the gene mutated in Van der Woude syndrome. Developmental Dynamics 235:1441-1447.
26.	Wang, Q., Lan, Y., Cho, E.-S., Maltby, K. M. and Jiang, R. (2005). Odd-skipped related 1 (Odd1) is an essential regulator of heart and urogenital development. Developmental Biology 288:582-594.
27.	Vieira, A.R., Avila, J. R., Daack-Hirsch, S., Dragan, E., Felix, T. M., Rahimov, F., Harrington, J., Schultz, R.R., Watanabe, Y., Johnson, M., Fang, J., O’Brien, S.E., Orioli, I.M., Castilla, E.E., FitzPatrick, D.R., Jiang, R., Marazita, M.L. and Murray, J.C. (2005). Direct sequencing of candidate genes for nonsyndromic cleft lip and palate. PLOS Genetics 1:e64.
28.	Jiang, R., Bush, J. O. and Lidral, A. C. (2006). Development of the upper lip: morphogenetic and molecular mechanisms. Developmental Dynamics 235:1152-1166 (RJ is first and corresponding author for this review article).
29.	Liu, H., Liu, W., Maltby, K. M., Lan, Y. and Jiang, R. (2006). Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation. Gene Expression Patterns (Mechanisms of Development) 6:632-636.
30.	Lan, Y., Ryan, R. C., Zhang, Z., Bush, J. O., Maltby, K. M., Bullard, S. A., Lidral, A. C. and Jiang, R. (2006). Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Developmental Dynamics 235:1448-1454.
31.	Casey, L. M., Lan, Y., Cho, E.-S., Maltby, K. M., Gridley, T. and Jiang, R. (2006). Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Developmental Dynamics 235:1830-1844.
32.	James, R.G., Kamei, C.N., Wang, Q., Jiang, R., and Schultheiss, T.M. (2006) Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development 15:2995-3004.
33.	Chen, J., Bush, J.O., Ovitt, C.E., Lan, Y. and Jiang, R. (2007). The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. Genesis, in press.
34.	Lan, Y., Wang, Q., Ovitt, C. E., and Jiang, R. (2007). A unique mouse strain expressing Cre-recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis, in press.

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