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NAME
DATE OF BIRTH
PLACE OF BIRTH
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Hervé LESOT
Feb. 11, 1951
Villers-Cotterets, France
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UNIVERSITY DEGREES AND PROFESSIONAL TRAINING
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1995 -
1990 -
1982-1990 -
1982-1983
1981-1982
1980
1974
1973-1981
1973 |
Team coordinator in the INSERM UMR 595
Director of research (DR2) CNRS , Institute of Medical Biology, Faculty of Medicine, Strasbourg
CR1 CNRS , Inst. of Medical Biology (Dir. J.V. Ruch)
P ost-doc fellow , Max-Planck Inst. for Biochemistry (Dr. K. von der Mark), Martinsried, Germany
CR2 CNRS , Institute of Medical Biology, Faculty of Medicine, Strasbourg.
Ph.D. Biochemistry , Faculty of Sciences, Louis Pasteur University (ULP), Strasbourg.
DEA Biochemistry, ULP, Faculty of Sciences, Strasbourg.
Attaché-Assistant , Inst. of Embryology, Faculty of Medicine, ULP, Strasbourg.
Master degree Biochemistry , Faculty of Sciences, ULP, Strasbourg.
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P OSITIONS RESEARCH AND SCIENTIFIC ACTIVITIES
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A) P ublications
Co-author of 109 publications in peer-reviewed journals, 6 book chapters, and participation to international meetings (46 presentations as invited speaker and co-author of 58 abstracts selected for oral presentation)
B) Scientific animation and research management
Since 1995, in charge of one of the three teams of the research unit INSERM UMR 595 , this team is focused on “Cell and molecular biology of dental morphofunctional differentiation”. The main axes of research are:
1) Morphogenesis and epithelial histogenesis relationships in the developing tooth.
2) X-linked ectodermal dysplasia
3) Tooth tissue engineering.
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| M EMBERSHIPS |
The Management Committee of the European COST B23 Action " Oral Facial Development and Regeneration " (2003-2008): Representant for France.
Japanese network ? Academic Frontier Project H15 on Tooth Morphogenesis ? (2003-2007), supported by the Japanese ESSCT Ministry
The European Cost Action B8 “Odontogenesis” (1996-2001)
The International Society for Developmental Biology since 1989
The International Society of Differentiation since 1988
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| TEACHING ACTIVITIES |
2006
2005-2007
2004
2003
2001 , 2003, 2006
1999
1995-1999
1982- 1990
1973-1981
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University of Illinois at Chicago .
teaching in the Master “Cell and molecular physiopathology”, School of Med., trasbourg.
Honorary Professor at the Capital Univ. of Medical Sciences, Faculty of Stomatology, Peking.
Invited professor at the School of Dentistry at Matsudo, Nihon University, Japan. Invited
professor at the Faculty of Medicine, Bari, Italy.
CES Anatomy and Morphogenesis , School of Medicine, Strasbourg.
DEA "Buccal and bone environment" (Dir.: Pr. N. Forest, Paris 7; Pr. M. Goldberg, Paris 5), Dental Schools, Univ. Paris 5 and Paris 7
DEA “Skeletal tissues and apatite's” (Dir.: Pr. R.M. Frank,) Dental School, Strasbourg
DEA “Biology and Biomaterials of Buccal and Bone environment (Dir.: Pr. M. Goldberg) Paris 5.
DEA “Molecular and cellular Biology” (Dir.: Dr. J. Hoffmann). Faculty of Science, Strasbourg
Students of year 1 and 2 from the Faculty of Medicine in Strasbourg
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| SELECTED PUBLICATIONS |
Yoshiba N., Yoshiba K., Stoetzel C., Perrin-Schmitt F., Cam Y., Ruch J.V., and Lesot H. Temporo-spatial gene expression and protein localization of matrix metalloproteinases and their inhibitors during mouse molar tooth development. Develop. Dyn., 2003, 228, 105-112.
Derbal L., Lesot H., Voegel J.C. and Ball V. Incorporation of alkaline phosphatase into layer-by-layer polyelectrolyte films on the surface of Affigel heparin beads : physicochemical characterization and evaluation of the enzyme stability. Biomacromolecules, 2003, 5, 1255-1263.
Nadiri A., Kuchler-Bopp S., Ha?kel Y. and Lesot H. Immunolocalization of BMP-2/-4, FGF-4 and WNT10b in the developing first lower molar in the mouse. J. Histochem. Cytochem., 2004, 52, 103-112.
Obara N. and Lesot H. Subcellular localization of ?-catenin and cadherin expression in the cap-stage enamel organ of the mouse molar. Histochem. Cell Biol., 2004, 121, 351-358.
Boran T, Lesot H., Peterka M. and Peterkova R. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J. Dent. Res., 2005, 84, 228-233.
Hu B., Nadiri A., Bopp-Kuchler S., Gendrault J.L. and Lesot H. Dental epithelial histo-morphogenesis in vitro. J. Dent. Res., 2005, 84, 521-525.
Hovorakova M., Lesot H., Peterka M. and Peterkova R. Origin of the deciduous upper lateral incisor and its clinical aspects. J. Dent. Res., 2006, 85, 167-171.
Hu B., Nadiri A., Kuchler-Bopp S., Perrin-Schmitt F., Peters H., and Lesot H. Tissue engineering of tooth crown, root and periodontium. Tissue Engineering, 2006, 12, 2069-2075.
Hu B., Unda F., Bopp-Kuchler S., Jimenez L., Wang X., Ha?kel Y., Wang S., and Lesot H. Bone marrow cells can give rise to ameloblast-like cells. J. Dent. Res. 2006, 85, 416-421.
Klein O.D., Minowada G., Peterkova R. Kangas A. Yu B.D., Lesot H., Peterka M., Jernvall J. and Martin G.R. Sprouty Genes Control Diastema Tooth Development via Bidirectional Antagonism of Epithelial-Mesenchymal FGF Signaling. Dev Cell. 2006, 11, 181-190. |
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