CURRICULUM VITAE
NAME
 Yang Chai
EDUCATION AND TRAINING

198 4
198 4-1986
199 1
199 1 -1994
1996

Stomatology, Peking University, Beijing, China
Oral-Maxillofacial Surgery, Peking University, Beijing, China
Craniofacial Biology, University of Southern California
Craniofacial Mol. Biol., University of Southern California
Dentistry, University of Southern California


P OSITIONS

1984-1986

Teaching Faculty and Surgical Resident, Department of Oral-Maxillofacial Surgery, School of Stomatology, Peking University

1987-1991 Research Associate, Graduate Program in Craniofacial Biology, School of Dentistry, University of Southern California

1991-Present

1991-1994

1991-1996
1996-2002
2002-2006
2004-Present

2006-Present
2007-Present

Course Director for Human Anatomy, School of Dentistry, University of Southern California
Postdoctoral fellows, Center for Craniofacial Molecular Biology, University of Southern California
Research Assistant Professor, School of Dentistry, University of Southern California
Assistant Professor, School of Dentistry, University of Southern California
Associate Professor, School of Dentistry, University of Southern California
Chairman, Division of Craniofacial Sciences and Therapeutics, School of Dentistry, USC
Professor, George and Mary Lou Boone Professor of Craniofacial Biology USC
Director, Center for Craniofacial Molecular Biology, School of Dentistry, USC

AWARDS AND HONOURS

1990-1991

1991
1995
1996
1996
1997
1997
2001-2003
2002-present

2004-present
2005-present 2004 , 2006

Certificate for Outstanding Academic Achievement, University of Southern California
PHI KAPPA PHI, All-University Honor Society, University of Southern California
Annual Teaching Award, University of Southern California, School of Dentistry
OKU Scholarship award for outstanding academic performance
Special recognition by the Dean for outstanding service and contribution to USC
James H. Zumberge Faculty Research and Innovation Award, USC
Annual Excellence in Teaching Award, University of Southern California
Award of Excellence in Teaching (every year), University of Southern California
NIH Ad hoc grant reviewer (OBM-2, ODCS) and Reviewer for the Welcome Trust, UK
Regular member of SBDD study section CSR NIH
Advisory Editorial Board for the journal ORAL DISEASE
Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration

SELECTED PEER-REVIEWED PUBLICATIONS
1. Chai Y, Klauser DK, Denny PA, Denny PC (1993). Proliferative and structural differences between male and female mouse submandibular glands. Anat. Rec. 235, 303-311.
2. Chai Y, Mah A, Crohin C, Groff S, Bringas P, Le T, Santos V, Slavkin, H.C. (1994). Specific transforming growth factor-beta subtypes regulate embryonic mouse Meckel's cartilage and tooth development. Dev. Biol. 162, 85-103.
3. Chai Y, Sasano Y, Bringas P, Mayo M, Slavkin HC, Shuler CF (1997). The characterization of the fate of midline epithelial cells during fusion of mandibular prominences in vivo. Dev. Dyn. 208, 526-535.
4. Chai Y, Bringas P Jr, Shuler C, Devaney E, Grosschedl R, Slavkin HC (1998). An early mandibular organ culture model developed to study cranial neural crest cell migration and molecular regulation of first branchial arch morphogenesis. Int. J Dev. Biol 42, 87-94.
5. Chai Y, Bringas P Jr, Slavkin HC (1998). PDGF-A and PDGFR-alpha Regulate Tooth Formation During Mandibular Morphogenesis In Vitro. Dev. Dyn. 213, 500-511.
6. Amano O, Bringas P, Takahashi I, Takahashi K, Yamane A, Chai Y, Nuckolls GH, Shum L, Slavkin HC (1999). Nerve Growth Factor (NGF) Induces Tooth Morphogenesis in Mouse First Branchial Arch Explants. Dev. Dyn. 216, 299-310.
7. Chai Y, Zhao J, Mogharei A, Xu B, Bringas P Jr, Shuler C, Warburton D (1999). Inhibition of Transforming Growth Factor beta Type II Receptor Signaling Accelerates Tooth Formation in Mouse First Branchial Arch Explants. Mech. Dev. 86, 63-74.
8. Chai Y, Jiang X, Ito Y, Bringas P Jr, Han J, Rowitch DH, Soriano P, McMahon AP, Sucov HM (2000). Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development, 127,1671-1679.
9. Zhao J, Crowe DL, Castillo C, Wuenschell C, Chai Y, Warburton D (2000). Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis. Mech. Dev. 93, 71-81.
10. Sarkar PS, Appukuttan B, Han J, Ito Y, Ai C, Tsai W, Chai Y, Stout JT, Reddy S (2000). Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Nature Genetics. 25, 110-114.
11. Acosta JM, Chai Y, Meara JG, Bringas P Jr, Anderson KD, Warburton D (2001). Prenatal exposure to nitrofen induces Fryns phenotype in mice. Ann. Plast. Surg. 46, 635-640
12. Ito Y, Zhao J, Mogharei A, Shuler CF, Weinstein M, Deng C, Chai Y (2001). Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development. J Biol Chem 276, 44163-44172.
13. Ito Y, Sarkar P, Mi Q, Wu N, Bringas P Jr, Liu Y, Reddy S, Maxson R, Deng C, Chai Y (2001). Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis. Dev. Biol. 236, 181-194.
14. Jaskoll T, Zhou Y, Chai Y, Makarenkova H, Collinson J, West J, Hajihosseini M, Lee J, Melnick M (2002). Embryonic Submandibular Gland Morphogenesis: Stage-Specific Protein Localization of FGFs, BMPs, Pax6 and Pax9 in Normal Mice and Abnormal SMG Phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) Mice. Cells Tissues Organs 170, 83-98.
15. Ito Y., Bringas P Jr, Mogharei A, Zhao J, Deng C, and Chai Y. (2002) Receptor-regulated and inhibitory Smads in regulating TGF-b-mediated Meckel’s cartilage development. Dev. Dyn. 224, 69-78.
16. Jitpukdeebodintra S, Chai Y, and Snead ML. (2002) Developmental patterning of the circumvallate papilla. Int. J. Dev. Biol. 46, 755-763.
17. Chai Y and Slavkin HC. (2003) Prospects of tooth regeneration in the 21st century: A perspective. Micros. Res. Tech. 60, 469-479.
18. Chai Y, Ito Y, and Han J. (2003) TGF-b signaling and its functional significance in regulating the fate of cranial neural crest cells. Crit. Rev. Oral Biol. Med. 14, 78-88.
19. Xu X, Jeong L, Han J, Ito Y, Bringas Jr P, and Chai Y. (2003) Developmental expression of Smad1-7 suggests critical function of TGF-b/BMP signaling in regulating epithelial-mesenchymal interactions during tooth morphogenesis. Int. J. Dev. Biol. 47, 31-39.
20. Zhang Y, Wang S, Han J, Chai Y, and Chen YP. (2003) Evidence for pre-patterned odontogenic neural crest. Dev. Dyn. 226, 713-718.
21. Cui XM, Chai Y, Chen J, Yamamoto T, Ito Y, Bringas Jr P, and Shuler CF. (2003) TGF-b3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion. Dev. Dyn. 227, 387-394.
22. Han J, Ito Y, Yeo J, Sucov HM, Maas R, and Chai Y. (2003) Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19INK4d expression during odontogenesis. Dev. Biol. 261, 183-196.
23. 23. Ito Y., Yeo JY, Chytil A, Han J, Bringas Jr P, Nakajima A, Shuler CF, Moses HL, and Chai Y. (2003) Conditional inactivation of TGF-b IIR in cranial neural crest causes cleft palate and calvaria defects. Development 130, 5269-5280.
24. Xu X, Bringas Jr P, Soriano P, and Chai Y. (2004). PDGFR-a signaling is critical for tooth cusp and palate morphogenesis. Dev. Dyn. 232, 75-84.
25. Sasaki T, Ito Y, Xu X, Han J, Bringas Jr P, Maeda T, Slavkin HC, Grosschedl R, and Chai Y. (2005) LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev. Biol. 278,130-143.
26. Cui XM, Shiomi N, Chen J, Saito T, Yamamoto T, Ito Y, Bringas Jr. P, Chai Y, Shuler C. (2005) Overexpression of Smad2 in TGF-b3-null mutant mice rescues cleft palate. Dev. Biol. 278, 193-202.
27. Jamora C, Lee P, Kocieniewski P, Azhar M, Hosokawa R, Chai Y, Fuchs E. (2005). A Signaling Pathway Involving TGF-beta2 and Snail in Hair Follicle Morphogenesis. PLoS Biol. 3:e11, 131-143.
28. Plikus, MV, Zeichner-David, M, Mayer, JA, Bringas, Jr, P, Thewissen, GM, Snead, ML, Chai, Y, Chuong, CM (2005) Morpho-regulation of teeth: Modulating induction, morphogenesis and differentiation events by tuning Bmp activity. Evolution and Development 7, 440-457.
29. Ishii, M, Han, J, Sucov, H, Chai, Y, and Maxson, RE (2005) Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development, 132, 4937-4950.
30. Zhao H, Bringas P Jr., Chai Y. (2005). An in vitro model for characterizing the post-migratory cranial neural crest cells of the first branchial arch. Dev. Dyn. 235, 1433-1440.
31. Hosokawa R, Urata MM, Ito Y, Bringas P Jr., Chai Y. (2005) Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing. Journal of Investigative Dermatology 125, 1302-1309.
32. Choudhary, B, Ito, Y, Chai, Y, and Sucov, H (2006) Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGF-b receptor (Tgfbr2) mutant mice. Dev. Biol., 289, 420-429.
33. Sasaki T, Ito Y, Bringas Jr. P, Chai Y (2006) TGF-b-mediated FGF signaling is critical for regulating cranial neural crest cell proliferation during frontal bone development. Development 133, 371-381.
34. Chai, Y and Maxson, Jr., RE (2006) Recent advances in craniofacial morphogenesis. Dev. Dyn., 235, 2353-2375.
35. Xu, X., Han, J., Ito, Y., Bringas, Jr., P., Urata, M., and Chai, Y. (2006) Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusion. Dev. Biol., 297, 238-248.
36. Dudas, M., Kim, J., Li, W.Y., Nagy, A., Larsson, J., Karlsson, S., Chai, Y. and Kaartinen, V. (2006) Epithelial and ectomesenchymal role of the type I TGF-β receptor ALK5 during facial morphogenesis and palatal fusion. Dev. Biol. 296, 298-314.
37. Oka, K., Oka, S., Sasaki, T., Ito, Y., Bringas, Jr., P., Nonaka, K., and Chai, Y. (2007) The role of TGF-b signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev. Biol. 303, 391-404.
38. Driskell, R., Goodheart, M., Neff, T., Liu, X., Luo, M., Moothart, C., Sigmund, C., Hosokawa, R., Chai, Y., Engelhardt (2007) Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev. Biol., 305, 90-102.
39. Oka, S., Oka, K., Xu, X., Sasaki, T., Bringas, P., Jr., and Chai, Y. (2007) Cell autonomous requirement for TGF-b signaling during odontoblast differentiation and dentin matrix formation. Mechanisms of Development 124, 409-415.
40. Han, J., Ishii, M., Bringas, Jr., P., Maas, R., Maxson, R., and Chai, Y. (2007) Concerted action of Msx1 and Msx2 in regulating cranial neural crest cells during frontal bone development. Mechanisms of Development 124, 729-745.
41. Pemberton TJ, Li F-Y, Oka S, Mendoza-Fandino GA, Hsu Y-S, Bringas P, Chai Y, Snead ML, Mehrian-Shai R, and Patel PI (2007). Identification of novel genes expressed during mouse tooth development by microarray gene expression analysis. Dev Dyn 236, 2245-2257.
42. Hosokawa, R., Urata, M., Han, J., Zehnaly, A., Bringas, Jr., P., Nonaka, K., Chai, Y. (2007). TGF-? mediated Msx2 expression controls occipital somites-derived caudal region of skull development. Dev. Biol. 310, 140-153.
43. Ko, S. O., Chung, I. H., Xu, X., Oka, S., Zhao, H., Cho, E. S., Deng, C. X., and Chai, Y. (2007). Smad4 is required to regulate the fate of cranial neural crest cells. Dev. Biol., (In Press).

 
 
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