CURRICULUM VITAE
NAME
 YiPing Chen
EDUCATION AND TRAINING

1982
1985
1993
1993-1994
1994-1996

Biology, Fujian Normal University, Fujian, China
Developmental Biology , Fujian Normal University, Fujian, China
Developmental Biology , the University of Iowa, Iowa City, IA
Developmental Biology , the University of Iowa, Iowa City, IA
Develop. Genetics , Harvard Medical School, Boston, MA

P OSITIONS
1996-1997

1997-2001
2001-2004

2001-2006

2004-2006
2006 - Present

Instructor, Harvard Medical School; Associate Geneticist, Brigham and Women's Hospital
Assistant Professor, Department of Cell and Molecular Biology, Tulane University
Associate Professor (tenured), Department of Cell and Molecular Biology, Tulane University
Director, Division of Developmental Biology, Department of CMB, Tulane University
Professor, Department of Cell and Molecular Biology, Tulane University
Professor, Section of Oral Biology, Ohio State University College of Dentistry

AWARDS AND HONOURS

National Research Service Award-NIH (1995);
Wang Kuan-Cheng Fellowship, Chinese Academy of Science, P.R. China (1999, 2001, 2003);
Established Investigator Award of American Heart Association (2003);
Winner of the CityBusiness Innovator of the Year, New Orleans, LA (2004);
The 2005 Provost's Research and Scholarly Achievement Award, Tulane University

C OMPLETED RESEARCH SUPPORT DURING LAST THREE YEARS

"Cell and protein signals in murine tooth development"
PI: YiPing Chen, Project 1.2
Agency: Louisiana Board of Regents (subcontract from LSU)
Type: HEF Center Grant (Paul Fidel, Director of the Center Grant)
Period: 7/1/00 - 6/30/05
M ajor goal of this project : identify the origin of the odontogenic potential in mouse.

SELECTED PEER-REVIEWED PUBLICATIONS
1. Chen, YP. and Solursh, M. (1991) The determination of myogenic and cartilage cells in the early chick embryo and the modifying effect of retinoic acid. Roux's Archives Dev. Biol. 195, 142-151.
2. Chen, YP. and Solursh, M. (1992) Comparison of Hensen's node and retinoic acid in secondary axis induction in the early chick embryo. Dev. Dynam. 195, 142-151.
3. Chen, YP., Huang, L., Russo, AF. and Solursh, M. (1992) Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chick embryo. Proc. Natl. Acad. Sci. USA 89, 10056-10059.
4. Chen, YP., Huang, L. and Solursh, M. (1994) A concentration gradient of retinoids in the early Xenopus laevis embryos. Dev. Biol. 161, 70-76.
5. Shen, RQ., Chen, YP.*, Huang, L., Vitale, E. and Solursh, M. (1994) Characterization of the human MSX-1 promoter and an enhancer responsible for the induction of retinoic acid. Cell. Mol. Biol. Res. 40, 297-312. (*: equal first author, and corresponding author)
6. Chen, YP., Kosteskii, I., Zile, MH. and Solursh, M. (1995) Comparative study of Msx-1 expression in Early normal and vitamin A-deficient avian embryos. J. Exp. Zool. 272, 299-310.
7. Chen, YP. and Solursh, M. (1995) Mirror-image duplication of the primary axis and heart in Xenopus embryo by overexpression of Msx-1 gene. J. Exp. Zool. 273, 170-174.
8. Chen, YP., Dong, D., Kostetskii, I. and Zile, MH. (1996) Hensen's node from vitamin A-deficient quail embryo induces chick limb duplication and retains its normal asymmetrical expression of Sonic hedgehog (Shh). Dev. Biol. 173, 256-264.
9. Chen, YP., Bei, M., Woo, I., Satokata, I. and Maas, R. (1996) Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development 122, 3035-3044.
10. Maas, R., Chen, YP., Bei, M., Woo, I. and Satokata, I. (1996) The role of Msx genes in mammalian development. Ann. N.Y. Acad. Sci. Vol. 785, 171-181.
11. Bei, M., Chen, YP., Woo, I., Satokata, I. Maas, R. (1996) Control of murine tooth development by the Msx genes. In "The Biological Mechanisms of Tooth Movement and Craniofacial Adaptation" by Z. Davidovitch, p431-439. Harvard Society for the Advancement of Orthodontics, Boston, MA. USA.
12. Chen, YP. and Maas, R. (1998) Signaling loops in the reciprocal epithelial-mesenchymal interactions of mammalian tooth development. In "Molecular Basis of Epithelial Appendage Morphogenesis" C-M. Chuong (ed.). R.G. Landes, Austin, TX, pp265-282.
13. St.Amand, TR., Jin, R., Zhang, YD., Hu, YP., Baber, SI., Qiu, MS. and Chen, YP. (1998) Cloning and expression pattern of chicken Pitx2: A new component in the SHH signaling pathway controlling embryonic heart looping. Biochem. Biophys. Res. Commun. 247, 100-105.
14. Chen, YP. and Zhao, X. (1998) Shaping limbs by apoptosis. J. Exp. Zool. 282, 691-702.
15. Li, CJ., Slaven, W.T.IV., Chen, YP. and John, V.T. (1998) In aqua synthesis of a high molecular weight areneethynylene polymer. Chem. Commun. 1351-1352.
16. Zhang, YD., Zhao, X., Hu, YP., St. Amand, T., Zhang, MF., Ramamurthy, R., Qiu, MS., and Chen YP. (1999) Msx1 is required for the induction of Patched by Sonic hedgehog in the ammalian tooth germ. Dev. Dynam. 215, 45-53.
17. Slaven, WT.IV., Li, CJ., Chen, YP., John, VT and Rachakonda, SH. (1999) In aqua synthesis of a high molecular weight arylethynylene polymer exhibiting reversible hydrogel properties. J. Macromole. Sci.-Pure Appl. Chem. A36(7&8), 971-980.
18. Cai, J., St.Amand, TR., Yin, H., Guo, H., Li, G., Zhang, YD., Chen, YP. and Qiu, MS. (1999) Expression and regulation of the chichen Nkx-6.2 homeobox gene suggests its possible involvement in the ventral neural patterning and cell fate specification. Dev. Dynam. 216, 459-468.
19. St.Amand, TR., Zhang, YD., Semina, E., Zhao, X., Hu, YP., Nguyen, L., Murray, J. and Chen, YP. (2000) Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth forming anlage. Dev. Biol. 217, 323-332.
20. Zhang, YD., Zhang, ZY., Zhao, X., Yu, XY., Hu, YP., Geronimo, B.,Fromm, SH. and Chen YP. (2000) A new function of BMP4: Dual role of BMP4 in regulation of Sonic hedgehog expression in the mouse tooth germ. Development 127, 1431-1443.
21. Zhang, ZY., Yu, XY., Zhang, YD., Geronimo, B., L?vlie, A., Fromm, SH. and Chen, YP. (2000) Targeted misexpression of constitutively active BMP receptor-IB causes bifurcation and duplication and posterior transformation of digit in mouse limb. Dev. Biol. 220, 154-167.
22. Zile, MH., Kostetskii, I., Yuan, S., Kostetskaia, E., St.Amand, TR., Chen, YP. and Jiang, W. (2000) Retinoid requirement for heart asymmetry specification during avian cardiogenesis. Dev. Biol. 223, 323-338.
23. Cai, J., Xu, X., Yin, H., Wu, W., Modderman, G., Chen, YP., Jensen, J., Hui, CC. and Qiu, MS. (2000) Evidence for the differential regulation of Nkx-6.1 expression in the ventral spinal cord and foregut by the Shh-dependent and -independent mechanisms. Genesis 27, 6-11.
24. Chen, YP., Zhang, YD., Jiang, T-X., Barlow, AJ., St. Amand, TR., Hu, YP., Heaney, S., Francis-West, P., Chuong, C-M. and Maas, R. (2000) Conservation of early odontogenic signaling pathways in Aves. Proc. Natl. Acad. Sci. USA. 97, 10044-10049.
25. Zhao, X., Zhang, ZY., Song, YQ., Zhang, X., Zhang, YD., Hu, YP., Fromm, SH. and Chen, YP. (2000) Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ. Mech. Dev. 99, 29-38.
26. Yu, XY., St. Amand, TR., Wang, SS., Li, G., Zhang, YD., Hu, YP., Nguyen, L., Qiu, MS. and Chen, YP. (2001) Differential expression and functional analysis of Pitx2 isoforms in regulation of heart looping in the chick. Development 128, 1005-1013.
27. Chuong, C-M., Hou, L., Chen, PJ., Wu, P., Patel, N. and Chen, YP. (2001). Dinosaur's feather and chicken tooth Tissue engineering of the integument. Eur. J. Dermato. 11, 286-292.
28. Linask, KK., Yu, XY., Chen, YP. and Han, MD. (2002) Directionality of heart looping: Effects of Pitx2c misexpression on flectin asymmetry and midline structures. Dev. Biol. 246, 407-417.
29. Zhang, ZY., Song, YQ, Zhao., X, Zhang, X., Fermin, C. and Chen, YP. (2002). Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and SHH signaling in the regulation of mammalian palatogenesis. Development 129, 4135-4146.
30. Zhang, YD., Wang, SS., Song, YQ., Han, J., Chai, Y., and Chen, YP. (2003). Timing of odontogenic neural crest cell migration and tooth-forming capability in mice. Dev. Dynam. 226, 713-718.
31. Zhang, ZY., Zhang, X., Avniel, WA., Song, YQ., Jones, SM., Jones, TA., Fermin, C. and Chen, YP. (2003). The malleal processus brevis is dispensable for normal hearing in mice. Dev. Dynam. 227, 69-77.
32. Zhang, ZY., Song, YQ., Zhang, X., Tang, J., Chen, J. and Chen, YP. (2003). Msx1/Bmp4 genetic pathway regulates mammalian alveolar bone formation via induction of Dlx5 and Cbfa1. Mech. Dev. 120, 1469-1479.
33. Suzuki, K., Bachiller, D., Chen, YP., Kamikawa, M., Ogi, H., Haraguchi, R., Ogino, Y., Minami, Y., Mishina, Y., Ahn, K., Crenshaw, EB, Yamada, G. (2003) Regulation of outgrowth and apoptosis for the terminal appendage, external genitalia, development by concerted functions of Bmp signaling. Development 130, 6209-6220.
34. Alappat, S., Zhang, ZY., and Chen, YP. (2003). Msx homeobox gene family and craniofacial development. Cell Res. 13, 429-442.
35. Wang, SS., Yu, XY., Zhang, T., Zhang, XY., Zhang, ZY., Chen, YP. (2004). Chick Pcl2 regulates the left- right asymmetry by repressing Shh expression in Hensen’s node. Development 131, 4381-4391.
36. Yu, XY., Wang, SS., Chen, YP. (2005). Expression and function of Pitx2 in chick heart looping. In "The Molecular Mechanisms of Axenfeld-Rieger Syndrome" Ed. B.A. Amendt. Landes Bioscience, Georgetown, TX. p65-73.
37. Alappat, S., Zhang, ZY., Suzuki, K., Zhang, XY., Liu, HB., Jiang, RL., Yamada, G., Chen, YP. (2005). The cellular and molecular etiology of cleft secondary palate in Fgf10 mutant mice. Dev. Biol. 277, 102-113.
38. Ogi, H., Suzuki, K., Ogino, Y., Kamimura, M., Myyado, M., Ying, X., Zhang, ZY., Shinohara, M., Chen, YP., Yamada, G. (2005). The ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice. Anat. Rec. 284A, 424-430.
39. Zhang, YD., Chen, Z., Song, YQ., Liu, C. and Chen, YP. (2005). Making a tooth: Growth factors, transcription factors, and stem cells. Cell Res. 15, 301-316.
40. Hilliard, SA., Yu, L., Gu, S., Zhang, ZY., and Chen, YP. (2005). Regional regulation of palatal growth and patterning Along the A-P axis in mice. J. Anat. 207, 655-667.
41. Yu, L., Gu, S., Alappat, S., Song, Y., Yan, M., Zhang, X., Zhang, G., Jiang, Y., Zhang, Z., Zhang, YD., Chen, YP. (2005). Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development 132, 4397-4406
42. Song, Y., Zhang, Z., Yu, XY., Yan, M., Zhang, X., Gu, S., Stuart, T., Liu, C., Reiser, J., Zhang, YD. and Chen, YP. (2006). Application of lentivirus-mediated RNAi in studying gene function in mammalian tooth development. Dev. Dyn. 235, 1347-1357.
43. Yamada, G., Suzuki., K., Haraguchi, R., Miyagawa,S., Satoh, Y., Nakagata, N., Kuroiwa, A., Chen, YP. (2006). Molecular genetic cascades for external genitalia formation: a glamorous organogenesis program. Dev. Dyn. 235, 1738-1752.
44. Wang, SS., He, F., Xiong, W., Gu, S., Liu, HB., Zhang, T., Yu, XY., Chen, YP. (2007). Polycomlike-2-deficient mice exhibit normal left-right asymmetry. Dev. Dyn. 236, 853-861.
45. Lin, D., Huang, Y., He, F., Gu, S., Zhang, G., Chen, YP. , Zhang, YD. (2007). An expression survey of genes critical for tooth development in human embryonic tooth germ. Dev. Dyn. 236, 1307-1312.
46. Yu, L., Liu, HB., Yan, M., Yang, J., Long, F., Muneoka, K. Chen, YP. (2007). Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol. 306, 549-559.
47. Espinoza-Lewis, RA., Yu, L., Wei, N., Sun, X., Martin, JF., Chen, YP. Shox2 is essential for the differentiation of cardiac pacemaker cells in mice. Development (in revision).
48. Key, D., Kist, R., Ogawa, T., Jonke,r L., Aw, A., Chen, YP., D’Souza, R., Maas, R., Heiko, P. Cleft lip, oligodontia and downregulation of Bmp4 signaling caused by disruption of synergistic Pax9-Msx1interactions. Development (submitted)
49. Chen, JF., Wang SS., Wu, Q., Cao, D., Nguyen, T., Chen, YP. Wang DZ. Myocardin marks the earliest cardiac gene expression and plays an important role in the chick heart development. Dev. Dyn. (submitted)
ONGOING RESEARCH SUPPORT
1. "Growth factor signaling pathways in mouse palatogenesis"
PI: YiPing Chen 　　　　　　　　Agency: NIH
Type: R01 DE14044 　　　　　　Period: 1/1/02 - 12/31/06 (no cost extension to 12/31/07)
The goal of this project is to study the role of growth factors including BMPs, Shh and FGFs in mammalian palatogenesis. Particularly function of these factors in establishing 3-dimentional development of the mouse palate is the main focus of this project.

2. “Molecular Mechanisms of Left-right Asymmetry”
PI: YiPing Chen 　　　　　　　Agency: American Heart Association National Research Center
Type: Established Investigator Award (0340166N) 　　　Period: 1/1/03 – 12/31/07
The goal of this project is to study the molecular mechanisms of embryonic left-right asymmetry and cardiac looping. Particularly we will focus on the role of a transcriptional repressor Pcl2 in the establishment of left-right asymmetry using chick and mouse as model systems.

3. “De Novo Generation of Mammalian Tooth from Stem Cells”
PI: YiPing Chen 　　　　　　　Agency: NIH
Type: R01 DE15123 　　　　　Period: 7/15/03 – 5/30/07 (no cost extension to 5/30/08)
The goal of this project is to induce bone marrow stromal cells to become odontogenic, and establish methodology to assembly tooth in vitro from stem cells.

4. "Molecular Mechanisms of Vertebrate Tooth Initiation"
PI: YiPing Chen　　　　　　　　　　 Agency: NIH
Type: 2 R01 DE12329 　　　　　　　Period: 2/1/04 - 1/31/09
The goal of this project is to continue the studies the role of BMP and Wnt signaling pathways in mammalian tooth initiation. Experiments using in vitro tissue recombination, organ culture, conditional gene knockout, gene knockdown via RNAi, and transgenic mice, will be performed.

5. “A New Strategy to Assess Gene Function in Tooth Formation”
PI: YiPing Chen 　　　　　　　　Agency: NIH
Type: R21 DE16623 　　　　　　Period: 4/1/05 – 2/28/07 (no cost extension to 2/28/08)
The goal of this project is to establish a methodology for large scale screen of gene function in mammalian tooth development using virus-mediated RNA interference.

6. “Shox2 in mammalian craniofacial development”
PI: YiPing Chen 　　　　　　　　Agency: NIH
Type: Pilot project in P50 DE16215 (PD: Jeff Murray)　　
Period: 8/1/05 – 7/31/06 (no cost extension to 7/31/07)
The goal of this pilot project is to study the role of the homeobox gene Shox2 in mammalian craniofacial development and its potential regulation by microRNA.

7. “Emergency aid for recovery of NIH supported research after Hurricane Katrina”
PI: YiPing Chen 　　　　　　　Agency: NIH
Type: R01 DE14044-05S1 　　Period: 1/1/06 – 12/31/06 (no cost extension to 12/31/07)
This is an emergency aid from the NIH to cover some of the losses of perishable reagents in the Chen lab during Hurricane Katrina and to provide immediate help for the recovery of the Chen lab’s research program supported by the NIH.


 
 
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