Graves, DT , Owen, AJ and Antoniades, HN. Evidence that a human osteosarcoma cell line which secretes a mitogen similar to platelet?derived growth factor requires growth factors present in platelet?poor plasma. Cancer Research . 43:83?87, 1983.

Graves, DT , Antoniades, HN, Whelms, SR and Owen, AJ. Evidence for functional platelet?derived growth factor receptors on MG?63 human osteosarcoma cells. Cancer Research . 44:2966?2970, 1984.

Antoniades, HN, Pantazis, P, Graves, DT , Owen, AJ and Tempst, P. Platelet?derived growth factor: A link to malignant transformation. Cancer Cells . 3:145?151, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., 1985

Graves, DT , Owen, AJ and Antoniades, HN. Demonstration of receptors for a PDGF?like mitogen on human osteosarcoma cells. Biochem Biophys Res Comm . 129:56?62, 1985.

Schwartz, CJ, Valente, AJ, Sprague, EA, Kelly, JL, Sueneram, CA, Graves, DT , Rozek, MM, Edwards, EH and Delgado, R. Monocyte?macrophage interactions in atherogenesis: Inflammatory components of pathogenesis. Seminars in Thrombosis and Hemostasis . 12:79?86, 1986.

Graves, DT , Owen, AJ, Williams, SR and Antoniades, HN. Identification of processing events in the synthesis of platelet?derived Growth factor?like proteins by human osteosarcoma cells. Proc Natl Acad Sci . USA, 83:4636?4640, 1986.

Valente, AJ, Delgado, R, Metter, JD, Cho, C, Sprague, EA, Schwartz, CJand Graves, DT. Cultured primate aortic smooth muscle cells express both the PDGF?A and PDGF?B genes but do not secrete a mitogenic platelet?derived growth factor?like protein. J Cellular Physiol . 136:479?485, 1988.

Richter, MR and Graves, DT. DNA synthesis in U?2 OS human osteosarcoma cells is independent of PDGF binding to functional PDGF cell surface receptors. J Cellular Physiol . 135:474?480, 1988.

Valente, AJ, Graves, DT , Vaille?Valentin, CE, Delgado, R and Schwartz, CJ. Purification of a monocyte chemotactic factor secreted by nonhuman primate vascular cells in culture. Biochemistry . 27:4162?4168, 1988.

Graves, DT and Antoniades, HN. Characterization of a high molecular weight protein immunoprecipitated by PDGF antisera. J Cellular Physiol . 137:263?271, 1988.

Graves, DT Grotendorst, GR, Antoniades, HN, Schwartz, CJ and Valente, AJ. Platelet?derived growth factor is not chemotactic for human peripheral blood monocytes. Experimental Cell Res . 180:497?503, 1989.

Piche, JE and Graves, DT. Study of the growth factor requirements of human bone?derived cells: A comparison with human fibroblasts. Bone . 10:131?138, 1989.

Piche, JE, Carnes, DL and Graves, DT. Initial characterization of cells derived from human periodontia. J Dent Res . 68:761?767, 1989.

Graves, DT , Valentin?Opran,A, Delgado,R, Valente,AJ, Mundy, GR, and Piche, JE. Platelet?derived growth factor as an autocrine and paracrine factor for bone cells. Connective Tissue Research . 23:209-218, 1989.

Graves, DT , Jiang, YL, Williamson, MJ, Valente, AJ. Identification of monocyte chemotactic activity produced by malignant cells. Science . 245:1490?1493, 1989.

Graves, DT and Cochran, DL. Mesenchymal cell growth factors. CRC Reviews in Oral Biology and Medicine . 1:17-36, 1990.

Adrian, GS, Yang, F, Graves, DT , Buchanan, JM and Bowman, BH. Expression of transferrin and vitamin D?binding protein genes in an osteogenic sarcoma cell line. Exp Cell Res . 186:385-389, 1990.

Graves, DT and Valente, AJ. Monocyte chemoattractants produced by malignant cells. (Editorial). J Pathol . 161:187-188, 1990.

Jiang, Y, Valente, AJ, Williamson, MJ, Zhang, L and Graves, DT. Post -translational modification of a monocyte-specific chemoattractant synthesized by glioma, osteosarcoma and vascular smooth muscle cells. Jnl Biol Chem . 65:18318-18321, 1990.

Valente, AJ, Rozek, MM, Schwartz, CJ and Graves, DT. Characterization of monocyte chemotactic protein 1 binding to human monocytes. Biochem Biophys Res Commun . 176:309-314, 1991.

Graves, DT and Valente, AJ. Monocyte chemotactic proteins from human tumor cells. Biochem Pharm . 41:333-337, 1991.

Zhang, L, Leeman, E, Carnes, DC and Graves, DT. Human osteoblasts synthesize and respond to platelet-derived growth factor. Am J Physiol . 261:C348-C354, 1991.

Jiang, Y, Tabak, LA, Valente, AJ and Graves, DT. Initial characterization of the carbohydrate structure of MCP-1. Biochem Biophys Res Commun . 178:1400-14004, 1991.

Graves, DT and Cochran, DL. Biologically active mediators: platelet-derived growth factor, monocyte chemoattractant protein-1, and transforming growth factor-B. Current Opinion in Dentistry . 1:809-815, 1991.

Gilardetti, RS, Chaibi, MS, Stroumza, J, Williams, SR, Antoniades, HN, Carnes, DC, and Graves, DT. High affinity binding of PDGF-AA and PDGF- BB to normal human osteoblastic cells and modulation by interleukin-1. Am J Physiol . 261:C980-C985, 1991.

Zhang, L, Leeman, E, Carnes, DC and Graves, DT. Human osteoblasts synthesize and respond to platelet-derived growth factor Am J Physio . 261:C348-C354, 1991.

Graves, DT , Barnhill, R, Galanopoulos, T, and Antoniades, HN. Expression of monocyte chemoattractant protein-1 in human melanoma in vivo. Am J Pathol . 140:9-14, 1992.

Jiang, Y, Beller, DI, Frendl, G, and Graves, DT. Monocyte chemoattractant protein-1 (MCP-1) regulates adhesion molecule expression and cytokine production in human monocytes. J Immunology . 148:2423-2428, 1992.

Antoniades, HN, Neville-Golden, J, Galanopoulos, T, Kradin, R, Bravo, M, Valente, A, Graves, DT. Monocyte chemotactic protein 1 expression in idiopathic pulmonary fibrosis, Proc Natl Acad Sci . (USA) 89: 5371-5375, 1992.

Williams, SR, Jiang, Yanling, Cochran, D, Dorsam, G and Graves, DT. Regulated expression of monocyte chemoattractant protein-1 in normal human osteoblastic cells. Am J Physiol . 32:C194-C199, 1992.

Antoniades, HN, Neville-Golden, J, Galanopoulos, T, Kradin, R, Bravo, M, Valente, A, Graves, DT. Monocyte chemotactic protein 1 expression in idiopathic pulmonary fibrosis, Proc Natl Acad Sci . (USA) 89: 5371-5375, 1992.

Williams, SR, Jiang, Yanling, Cochran, D, Dorsam, G and Graves, DT. Regulated expression of monocyte chemoattractant protein-1 in normal human osteoblastic cells. Am J Physiol . 32:C194-C199, 1992.

Cochran, DL, Rouse, CA, Lynch, SE, and Graves, DT. Effects of platelet-derived growth factor isoforms on calcium release from neonatal mouse calvariae. Bone . 14:53-58, 1993.

Yeh, EH, Kang, YM, Chaibi, MS, Xie, JF, Graves, DT . Interleukin-1 and transfor-ming growth factor-$ inhibit PDGF-AA binding to osteoblastic cells by reducing PDGF-" receptor expression. J Immunology . 150:5625-5631, 1993.

Yu XH, Antoniades HN, Graves DT. Expression of monocyte-chemoattractant protein-1 in human inflammed gingival tissues. Infect Immun . 61:4622-4628, 1993.

Zhu, J, Valente, AJ, Lorenzo, JA, Carnes, D and Graves, DT . Expression of monocyte chemoattractant protein-1 (MCP-1) in human osteoblastic cells is stimulated by pro-inflammatory mediators. J Bone Min Res . 9:1123-1130, 1994.

Yu, X, Barnhill, RT and Graves, DT . Expression of monocyte chemoattractant protein-1 (MCP-1) in delayed type hypersensitivity reactions in the skin. Laboratory Investigation . 71:226-235, 1994.

Xie, JF, Stroumza, J, Graves, DT . IL-1 downregulates PDGF-" receptor gene expression at the transcriptional level in human osteoblastic cells. Journal of Immunology . 153:378-383, 1994.

Jiang, YL, Zhu, JF, Luscinskas, WF, and Graves DT. MCP-1-stimulated monocyte attachment to laminin is mediated by B2-integrins. American Journal of Physiology . 267:C1112-C1118, 1994.

Yu, X and Graves, DT. Fibroblasts, mononuclear phagocytes and endothelial cells express MCP-1 in inflamed human gingiva. Journal of Periodontology . 66:80-88, 1995.

Kang, YM, Yeh, IH, and Graves, DT. Interleukin-1 modulates phosphorylation of proteins in human osteoblastic cells. J Bone Min Res . 10:96-105, 1995.

Rahimi, P, Wang, CY, Stashenko, P, Lee, SK, Lorenzo, JA and Graves, DT . MCP-1 expression and monocyte recruitment in osseous inflammation. Endocrinology . 136:2752-2759, 1995.

Graves, DT and Jiang, YL. Chemokines: a family. Critical Reviews in Oral Biology . 6:109-118, 1995.

Penberthy, TP, Jiang Y, Luscinskas, FW, and Graves, DT , B 2 -Intergrins preferentially mediate monocyte chemoattractant protein-1 (MCP-1) induced monocyte migration on extracellular matrix proteins. Am J Physiol . 269:C60-C68, 1995.

Oates, TW, Kose, K, Xie, JF, Graves, DT , Collins, JM and Cochran, DL. Receptor binding of PDGF-AA and PDGF-BB and the modulation of PDGF receptor by TGF-B in human PDL cells. J Cell Physiol . 162:3559-3366, 1995.

Kose, KN, Xie JF, Carnes DL and Graves, DT . Pro-inflammatory cytokines downregulate platelet derived growth factor- a receptor gene expression in hum osteoblastic cells. Journal of Cellular Physiology . 166:188-197,1996.

Young, S J, Chaibi, MS, Graves , DT, Boustany, F, Cochran, D and P Nummikoski. Quantitative analysis of periodontal defects in a skull model by subtraction radiography using radiovisiography. J Periodont . 67:763-769, 1996.

YL Jiang, TR Russell, DT Graves , H Cheng, S Nong and SM Levitz. Monocyte chemoattractant protein-1 and interleukin-8 production in mononuclear cells stimulated by oral microorganisms. Infect Immun . 64(11):4450-5, 1996.

Calias, P, Galanopoulos, T, Maxwell, M, Khayat, A, Graves, DT, Antoniades, HN, d'Alarcao, M. Synthesis of inositol 2-phosphate-quercetin conjugates. Carbohydrate Research . 292:83-90, 1996.

Graves, DT . The use of biologic response modifiers in human clinical trials. American Academy of Periodontology Consensus Conference on Clinical Trials. Ann Periodontol . 2:259-67, 1997.

Jiang, YL, Russell, TR, Schilder, H and Graves DT . Endodontic pathogens stimulate monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (Il-8) in mononuclear cells. J Endodontics . 24:86-90, 1998.

Barnhill, RL, Xiao, M, Graves, DT and Antoniades, HN. Expression of PDGF-A, PDGF-B and the PDGF-alpha receptor, but not the PDGF-beta receptor in human melanoma in vivo. B J Cancer . 135(6):898-904, 1996.

Yu, X, Hsieh, S, Bao W, and Graves DT . Temporal expression of PDGF receptors and PDGF regulatory effects on osteoblastic cells in long-term mineralizing cultures. Am. J. Physiology: Cell Physiology . 272:1709-1716, 1997.

Zhang, L, Khayat, A, Cheng, HS. Graves DT . The pattern of monocyte recruitment in tumors is modulated by mcp-1 expression and influences the rate of tumor growth. Laboratory Investigation . 6:579-590, 1997.

Volejnikova, S, Laskari, M, Marks, SC and Graves, DT. Monocyte recruitment and expression of monocyte chemoattractant protein-1 are developmentally regulated in remodeling bone in the mouse. Am J Pathol . 150:1711-1721, 1997.

Zhang, L, Yoshimura, T and Graves, DT. Antibody to Mac-1 or monocyte chemoattractant protein-1 inhibits monocyte recruitment and promotes tumor growth. J Immunology . 158:4855-4861, 1997.

Graves, DT, and Zhang L. “Chemokine expression in inflammation”. Studies in Stomatology and Craniofacial Biology , pp427-444. ed. M.M. Cohen and B.J. Baum, IOS Press, Amsterdam, Netherlands, 1997.

Carnes, DL,. Maeder, CL, and Graves DT . Cells with osteoblastic phenotypes can be explanted from human gingiva and periodontal ligament. Journal of Periodontology . 68:701-7, 1997.

Faller, DV, Weng, H, Graves DT, and Choi SY. Moloney murine leukemia virus long terminal repeat activates monocyte chemotactic protein-1 protein expression and chemotactic activity. Journal of Cellular Physiology . 172:240-52, 1997.

Posner, LJ, Miligkos, T, Gilles, JA, Carnes, DL, Taddeo, DR and Graves, DT . Monocyte chemoattractant protein-1 induces monocyte recruitment that is associated with an increase in numbers of osteoblasts. Bone . 21:321-327, 1997.

Hsieh, SC and Graves, DT . Pulse application of PDGF enhances formation of a mineralizing matrix while continuous application is inhibitory. J Cell Biochem . 62:169-180, 1998.

Valente, AJ, Xie, J, Abramova, MA, Wenze, UO, Abboud, HE and Graves, DT. A complex element regulates IFN-gamma-stimulated monocyte chemoattractant protein-1 gene transcription. J Immunol . 161:3719-28, 1998.

Graves, DT, Delima, A, Assuma, R, Amar, S, Oates, T and Cochran, DL. IL-1 and TNF antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in experimental periodontitis. J Periodontology . 69:1419-25, 1998.

Ciang, CY, Kyritsis, G, Graves, DT and Amar, S. Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide. Infect Immun . 67:4231-4236, 1999.

Graves, DT , Chen, CP, Douville, C and Jiang Y. IL-1 receptor signaling rather than that of TNF is critical in protecting the host from the severe consequences of a polymicrobial anaerobic infection. I nfect Immun . 68:4746-51, 2000.

Graves, DT , Nooh, N, Gillen, T, Davey, M, Patel, S, Cottrell, D, and Amar S. Il-1 plays a critical role in oral, but not dermal wound healing. J Immunol . 167:5316-20, 2001.

Graves, DT , Oskoui, M, Volejnikova, S, Naguib, G, Cai, S, Desta, T, Kakouras, A and Jiang Y. TNF modulates fibroblast apoptosis, PMN recruitment, and osteoclast formation in response to P. gingivalis infection. J Dent Res . 80: 1875-9, 2001.

Kon, T, Cho, TJ, Aizawa, T, Yamzaki, M, Nooh, N, Graves, DT , Gerstenfeld, LC and Einhorn TA. Expression of osteoprotegerin receptor activator of NF-kappaB ligand (Osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J Bone Miner Res . 16:1004-14, 2001.

Delima, AJ, Karatzas, S, Amar, S, and Graves DT . Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukine-1 antagonists. J Infect Dis . 186:511-6, 2002.

Volejnikova, S, Marks, SC Jr, and Graves DT . Tumor necrosis factor modulates apoptosis of monocytes in areas of developmentally regulated bone remodeling. J Bone Miner Res . 17:991-7, 2002.

Graves, DT, Alsulaimani, F, Ding, Y, Marks, SC Jr. Developmentally regulated monocyte recruitment and bone resorption are modulated by functional deletion of the monocytic chemoattractant protein-1 gene. Bone . 31:282-7, 2002.

Gerstenfeld, LC, Cullinane, DM, Barnes, GL, Graves, DT and Einhorn, TA. Fracture healing as a developmental process: Molecular, spatial, and temporal aspects of its regulation. J Cell Biochem . 88:873-84, 2003.

Lu, H, Kraut, D, Gerstenfeld, LC, and Graves DT . Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation. Endocrinology . 144:346-52, 2003.

Nooh, N and Graves, DT. Healing is delayed in oral compared to dermal excisional wounds. J Periodontol . 74:242-6. 2003.

Gerstenfeld, LC, Cho, TJ, Kon, T, Aizawa, T, Tsay, A, Fitch, J, Barnes, GL, Graves, DT and Einhorn TA. Impaired facture healing the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption. J Bone Miner Res . 18: 1584-92. 2003

Santana, RB, Xu, L, Chase, HB, Amar, S, Graves DT and Trackman, PC. A role for advanced glycation end products in diminished bone healing in type 1 diabetes. Diabetes . 52:1502-10. 2003.

Graves, DT, and Cochran, D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontal . 74:391-401. 2003.

Alikhani, M, Alikhani, Z, He, H, Liu, R, Popek, BI and Graves, DT. Lipopolysaccharides indirectly stimulate apoptosis and global induction of apoptotic genes in fibroblasts.
J Biol Chem . 278:52901-8. 2003.

He, H, Liu, R, Desta, T, Leone, C, Gerstenfeld, LC and Graves, DT . Diabetes causes decreased osteoclastogenesis, reduced bone formation, and enhanced apoptosis of osteoblastic cells in bacteria stimulated bone loss. Endocrinology . 145: 447-52, 2004.

Alikhani, M, Alikhani, Z and Graves, DT. Apoptotic effects of LPS on fibroblasts are indirectly mediated through TNFR1. J Dent Res . 83:671-676, 2004.

Chi, H, Messas, E, Levine, RA, Graves, DT and Amar, S. Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications. Circulation . 110:1678-85, 2004.

Lu, H, Raptis, M, Black, E, Stan, M, Amar, S and Graves DT . Influence of diabetes on the exacerbation of an inflammatory response in cardiovascular tissue. Endocrinology . 145:4934-4939, 2004.

Zhang, X, Kohli, M, Zhou, Q, Graves, DT and Amar S. Short- and long-term effects of IL-1 and TNF antagonists on periodontal wound healing. J Immunol . 173:3514-23, 2004.

Naguib, G, Al-Mashat, H, Desta, T, Graves, DT . Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation. J Invest Dermatol . 123:87-92. 2004.

Liu, R, Desta, T, He, H and Graves, DT . Diabetes alters the response to bacteria by enhancing fibroblast apoptosis. Endocrinology .145:2997-3003. 2004.

He, H, Liu, R, Desta, T, Leone C, Gerstenfeld, LC and Graves DT. Diabetes causes decreased osteoclastogenesis, reduced bone formation, and enhanced apoptosis of osteoblastic cells in bacteria stimulated bone loss. Endocrinology . 145:447-52. 2004.

Alikhani, M, Alikhani, Z, Raptis, M and Graves, DT . TNF-a in vivo stimulates apoptosis in fibroblasts through caspase-8 activation and modulates the expression of pro-apoptotic genes. J Cell. Physiol . 201:341-8, 2004.

Graves, DT , Naguib, G, Lu, H, Leone, C, Hsue, H and Krall, E. Inflammation is more persistent in type 1 diabetic mice. J Dent Res . 84:324-8, 2005.

Graves, DT , Naguib, G, Lu, H, Desta, T and Amar S. Porphyromonas gingivalis fimbriae are proinflammatory but do not play a prominent role in the innate immune response to P. gingivalis. J Endotoxin Res . 11:13-8. 2005.

Lehmann, W, Edgar, CM, Wang, K, Cho, TJ, Barnes, GL, Kakar, S, Graves, DT , Rueger,

JM, Gerstenfeld, LC and Einhorn TA. Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing. Bone . 36:300-310, 2005.

Zhou, Q, Desta, T, Fenton, M, Graves, DT and Amar, S. Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun . 73:935-43, 2005.

Alikhani, Z, Alikhani, M, Boyd, C, Nagao, K, Trackman, PC and Graves DT . Advanced glycation endproducts enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial pathways. J Biol Chem . 280:12087-95 2005

Alikhani, M, Alikhani, Z and Graves, DT . FOXO1 functions as a master switch that regulates gene expression necessary for TNF-induced fibroblast apoptosis. J Biol Chem . 280:12096-102. 2005.

Graves, DT , Liu, R, Alikhani, M, Al-Mashat, H and Trackman PC. Diabetes-enhanced inflammation and apoptosis-impact on periodontal pathology. J Dent Res . 85:15-21.2006.

Al-Mashat, HA, Kandru, S, Liu, R, Behl, Y, Desta, T and Graves DT . Diabetes enhances mRNA levels of pro-apoptotic genes and caspase activity which contribute to impaired healing. Diabetes . 55:487-95. 2006.

Leone, CW, Bokhadhoor, H, Kuo, D, Desta, T, Yang, J, Siqueira, MF, Amar, S and Graves DT . Immunization enhances inflammation and tissue destruction in response to Porphyromonas gingivalis. Infect Immun . 74:2286-92. 2006.

Liu, R, Bal, HS, Desta, T, Behl, Y and Graves DT . Tumor necrosis factor mediates diabetes-enhanced apoptosis of matrix producing cells and impairs diabetic healing. Am J Pathol . 168:757-64.2006.

Gerstenfeld LC, Alkhiary YM, Krall EA, Nicholls FH, Stapleton SN, Fitch JL, Bauer M, Kayal R, Graves DT , Jepsen KJ, Einhorn TA. Three-dimensional reconstruction of fracture callus morphogenesis. J Histochem Cytochem. 54:1215-28. 2006

Alikhani, M, MacLellan , C., Raptis, M., Vora, S., Trackman, PC, and Graves, DT . Advanced glycation endproducts induce apoptosis in fibroblasts through activation of ROS, MAP kinases and the FOXO1 transcription factor, Am. J. Physiol Cell Physiol. 292:C850-6.2007.

Graves DT , Liu R, Oates TW. Diabetes-enhanced inflammation and apoptosis: impact on periodontaol pathosis. Periodontol 2000. 45:128-37.2007.

Desta T, Graves DT . Fibroblast apoptosis induced by Porphyromonas gingivalis is stimulated by a gingipain and caspase-independent pathway that involves apoptosis-inducing factor. Cell Microbiol. 9:2667-75.2007.

Kayal RA, Tsatsas D, Bauer MA, Allen B, Al-Sebaei MO, Kakar S, Leone CW, Morgan EF, Gerstenfeld LC, Einhorn TA, Graves DT . Diminished bone formation during diabetic fracture healing is related to the premature resoption of cartilage associated with increased osteoclast activity. J Bone Miner Res. 22:560-8.2007.

Alikhani M, Alikhani Z, Boyd C, Maclellan CM, Raptis M, Liu R, Pischon N, Trackman PC, Gerstenfeld L, Graves DT . Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways. Bone. 40:345-53. 2007.

Graves DT , Kayal RA. Diabetic complications and dysregulated innate immunity. Front Biosci. 13:1227-39. 2008

RESEARCH SUPPORT

Previous Research Support (selected)

1) NIH ? R23 DE07559

Principal Investigator

1984?1987

$107,500

2) NIH - R01 DE07559

Principal Investigator

Granting period: 7/1/88 to 6/30/92

Annual direct costs: Approximately $64,000

3) NIH ? R03 DE07556

Principal Investigator

1985?1986

$15,000

4) NIH ? R03 DE07733

Principal Investigator

1986?1987

$15,000

5) NIH RO1 HL38390, Principal Investigator, Dr. Anthony Valente,

Co?Principal Investigator

Granting period: 4/1/87 to 3/31/90

Annual direct costs to Dr. Graves: Approximately $20,100.

6) NIH - RO1 DEO9581

“Autocrine Stimulation in Normal Bone Cells”

Principal Investigator

Granting period: 8/30/90 to 8/29/95

Annual direct costs approximately $133,000

7) NIH - R01 DE07559

“Bone-derived Cells Produce a Chemotactic Factor”

Principal Investigator

Granting period: 7/1/92 to 6/30/97

Annual direct costs: Approximately $138,000

9) NIH, R01 DE11254

“Mechanisms of Periodontal Destruction”

Principal Investigator

Granting period: 4/1/95 to 3/31/99

Annual direct costs approximately $183,000

8) NIH - R01 DE07559

“Bone-derived Cells Produce a Chemotactic Factor”

Principal Investigator

Granting period: 7/1/97 to 6/30/02

Annual direct costs: Approximately $145,000

9) NIH, R01 “Growth Factors Gingival Fibrosis”

Co-Investigator (PI P. Trackman, Department of Periodontology and Oral Biology, BUSDM)

Granting period: 11/1/02 to 10/31/06

Present Research Support

1) NIH, R01 DE07559 “Bone-derived Cells Produce a Chemotactic Factor”

Principal Investigator

Granting period: 03/31/04 - 3/31/08 (administrative extension granted)

2) NIH, P01 AR49920 “Molecular Mechanisms of Skeletal Repair”

Director: Core B and Project 3 (PI. T. Einhorn, Department of Orthopedics, BUSM). Granting period: 06/15/04 to 5/31/09

3) NIH, R01 DE14066 “Inhibited Intramembranous Bone Healing in Diabetes”

Co-Investigator (PI P Trackman, Department of Periodontology and Oral Biology, BUSDM). Granting period: 06/01/03-05/31/08

4) NIH, R01 DE018307 “Recognition of Commensal and Pathogenic Bacteria By Oral Epithelium” Principal Investigator

Granting period: 07/01/2007 - 6/30/2012

5) NIH, R01 DE17732 “Diabetes-enhanced Experimental Periodontitis” Principal Investigator

Granting period: 07/01/2007- 6/30/2012

Pending Research Support

1) NIH “Impaired Healing and Fibroblast Apoptosis in Diabetes”. Proposed period of support: 7/07 to 6/12.

2) United States-Israel Bionational Science Foundation (BSF) “Effects of type 1 Diabetes on Osteoprogenitor Cells: Mechanisms and Intervention” Proposed period of support: 09/01/08 – 08/31/2010.