CURRICULUM VITAE
NAME	Toshiyuki Yoneda
PLACE OF BIRTH	Osaka, Japan
OFFICE ADDRESS	Department of Biochemistry, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan
	Phone: 81-6-6879-2886; Fax: 81-6-6879-2890;
	E-mail: tyoneda@dent.osaka-u.ac.jp
EDUCATION, DEGREES, AND DIPLOMAS
1987	Diplomate, Subspeciality Boards in Oral & Maxillofacial Surgery
1976	Ph.D. (Doctor of Philosophy, Osaka University, Graduate School, Biochemistry)
1972	D.D.S. (Doctor of Dental Surgery, Osaka University Faculty of Dentistry)
	Diplomate, Japanese Board of Dentistry
WORKING EXPERIENCE
2007-present	Dean, Osaka University Graduate School of Dentistry
2005-present	Member of the Japanese Science Council
2003-present	Leader of 21 st Century COE Program
2003-2004	Council Member of Osaka University
1997-present	Professor and Chairman, Department of Biochemistry, Osaka University Graduate School of Dentistry, Suita,Osaka, Japan
2001-present	Heyser Professor and Chief of Endocrine Research, Department of Medicine, University of Texas HealthScience Center at San Antonio, San Antonio, Texas, USA
1995-1997	Professor, Department of Medicine, Division of Endocrinology and Metabolism, University of Texas HealthScience Center at San Antonio, San Antonio, Texas, USA
1993-1995	Associate Professor, Department of Medicine, Division of Endocrinology and Metabolism, and Department ofPeriodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
1992-1993	Professor and Chairman, Division of Molecular Cell Biology, Medical Science Institute, Tokyo Medical andDental University, Tokyo, Japan
1987-1992	Assistant Professor, Division of Endocrinology and Metabolism, Department of Medicine, University of TexasHealth Science Center at San Antonio, San Antonio, Texas, USA
1980-1987	Assistant Professor, Second Department of Oral and Maxillofacial Surgery,saka University School of Dentistry, Suita, Osaka, Japan

PUBLICATIONS
1.	Sasaki A, Boyce BF, Story B, Wright KR, Chapman M, Boyce R, Mundy GR, Yoneda T: Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice. Cancer Res 55:3551-3557, 1995
2.	Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, Boyce BF: Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 10:1478-1487, 1995
3.	Moriyama K, Williams PJ, Niewolna M, Dallas MR, Uehara Y, Mundy GR, Yoneda T: Herbimycin A, a tyrosine kinase inhibitor, impairs hypercalcemia associated with a human squamous cancer producing interleukin-6 in nude mice. J Bone Miner Res 11:905-911, 1996
4.	Izbicka E, Yoneda T, Takaoka Y, Horn D, Williams P, Mundy GR: Identification of a novel bone/calcium metabolism-regulating factor in porcine pancreas. J Biol Chem 271:23230-23234, 1996
5.	Mbalaviele G, Dunstan CR, Sasaki A, Williams PJ, Mundy GR, Yoneda T: E-cadherin expression in human breast cancer cells suppress the development of osteolytic bone metastases in experimental metastasis model. Cancer Res 56:4063 – 4070, 1996
6.	Guise TA, Yin JJ, Taylor SD, Kumagai Y, Dallas M, Boyce BF, Yoneda T, Mundy GR: Evidence for a causal role of a parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest 98:1544-1549, 1996
7.	Yoneda T, Sasaki A, Dunstan C, Williams PJ, Bauss F, De Clerck YA, Mundy GR: Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2. J Clin Invest 99:2509-2517, 1997
8.	Nishimura R, Kato Y, Chen D, Harris SE, Mundy GR, Yoneda T: Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J Biol Chem 273: 1872-1879, 1998
9.	Nishimura R, Moriyama K, Yasukawa K, Mundy GR, Yoneda T: Modulation of differentiation and proliferation of MG-63 human osteoblastic cells by combination of inteleukin-6 and soluble forms of interleukin-6 receptors is associated with an activation of JAK-STAT and MAP kinase pathways. J Bone Miner Res 13:777-785,1998
10.	Mbalaviele G, Nishimura R, Myoi A, Niewolna M, Reddy SV, Chen D, Feng J, Roodman D, Mundy GR, Yoneda T: Cadherin-6 mediates the heterotypic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiation. J Cell Biol 141:1467-1476, 1998
11.	Mundy GR, Yoneda T: Bisphosphonates as anticancer drugs. N. Engl. J. Med., 339:398-400, 1998
12.	Jackson JG, Yoneda T, Clark GM, Yee D: Elevated levels of p66 Shc are found in breast cancer cell lines and primary tumors with high metastatic potential. Clin Cancer Res 6:1135-1139, 2000
13.	Yoneda T, Michigami T, Yi B, Williams PJ, Niewolna M, Hiraga T: Actions of bisphosphonate on bone metastasis in animal models of breast cancer. Cancer 88: 2979-2988, 2000
14.	Michigami T, Shimizu N, Williams PJ, Niewolna M, Dallas SL, Mundy GR, Yoneda T: Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and a4b1 integrin enhances production of osteoclast-stimulating activity. Blood 96:1953-1960, 2000
15.	Marzia M, Sims NA, Voit S, Migliaccio S, Taranta A, Bernadini S, Faraggiana T, Yoneda T, Mundy GR, Boyce BF, Baron R, Teti A: Decreased c-src expression enhances osteoblast differentiation and bone formation. J Cell Biol 151:311-320, 2000
16.	Oyajobi BO, Anderson DM, Traianedes, Williams PJ, Yoneda T, Mundy GR. Therapeutic efficacy of a soluble RANK-IgG Fc (RANK.Fc) fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy. Cancer Res 61: 2572-2578, 2001
17.	Hiraga T, Williams PJ, Mundy GR, Yoneda T: The bisphosphonate ibandronate promotes apoptosis in MDA-231 human breast cancer cells in bone metastases. Cancer Res 61: 4418-4424, 2001
18.	Yoneda T, Williams PJ, Hiraga T, Niewolna M, Nishimura R: A bone-seeking subclone exhibits different properties from the parental MDA-MB-231 human breast cancer cells and a brain-seeking subclone in vivo and in vitro. J Bone Miner Res 16:1486-1495, 2001
19.	Cruz JC, Alsina M, Craig F, Yoneda T, Anderson JL, Dallas M, Roodman GD: Ibandronate decreases bone disease development and osteoclast stimulatory activity in an in vivo model of human myeloma. Exp Hematol 29: 441-447, 2001
20.	Jackson JG, Zhang X, Yoneda T, Yee D: Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines. Oncogene 20: 7318-7325, 2001
21.	Yi B, Williams PJ, Niewolna M, Wang Y, Yoneda T: Tumor-derived PDGF-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer. Cancer Res 62:917-923, 2002
22.	Michigami T, Hiraga T, Williams PJ, Nishimura R, Mundy GR, Yoneda T: The effect of the bisphosphonate ibandronate on breast cancer metastasis to visceral organs. Breast Cancer Res Treat 75:249-258, 2002
23.	Wang F, Hansen RK, Radisky D, Yoneda T, Barcellos-Hoff MH, Petersen OW, Turley EA and Bissell MJ. Combined alteration of intracellular signaling pathways in a three-dimensional context leads to phenotypic reversion or cell death of human breast cancer cells. J Natl Cancer Inst 94:1494-1503, 2002
24.	Hiraki A, Ueoka H, Bessho A, Segawa Y, Takigawa N, Kiura K, Tabata M, Shibayama T Gemba K, Eguchi K, Hiraki S, Yoneda T, Harada M: Parathyroid hormone-related protein measured at first visit is an indicator for bone metastases and survival in lung cancer patients with hypercalcemia. Cancer 95:1706-1713, 2002
25.	Hata K, Nishimura R, Ikeda F, Yamashita K, Matsubara T, Nokubi T, Yoneda T: Differential roles of Smad1 and p38 kinase in the regulation of PPAR? during BMP2-induced adipogenesis. Mol Biol Cell 14:545-555, 2003
26.	Myoui A, Nishimura R, Williams PJ, Hiraga T, Tamura D, Michigami T, Mundy GR and Yoneda T: C-Src tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis. Cancer Res 63:5028-5033, 2003
27.	Hiraga T, Ueda A, Tamura D, Hata K, Williams PJ, Ikeda F, Yoneda T: Effects of oral UFT combined with or without zoledronic acid on distant metastasis in the 4T1/luc mouse breast cancer Int J Cancer 106:973-979, 2003
28.	Hiraga T, Williams PJ, Ueda A, Tamura D, Yoneda T: Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model. Clin Cancer Res 10:4559-4567, 2004
29.	Ichida F, Nishimura R, Hata K, Matsubara T, Ikeda F, Hisada K, Yatani H, Cao X, Komori T, Yamaguchi A, Yoneda T. Reciprocal roles of Msx2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem 279: 34015-34022, 2004
30.	Mori Y, Shimizu N, Dallas M, Niewolna M, Story B, Williams PJ, Mundy GR, Yoneda T: Anti-a4 integrin antibody suppresses the development of multiple myeloma and associated with osteoclastic osteolysis. Blood 104: 2149-2154, 2004
31.	Ikeda F, Nishimura R, Matsubara T, Tanaka S, Inoue J, Reddy S, Hata K, Yamashita K, Hiraga T, Watanabe T, Kukita T, Yoshioka K, Rao A, Yoneda T. Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest 114: 475-484, 2004
32.	Kitagawa Y, Hiraga T, Yura Y, Yoneda T. Suppression by incadronate of invasion and growth of A-375 human melanoma in mandible in nude mice. Oncol Report 13: 211-216, 2005
33.	Hata K, Nishimura R, Ueda M, Ikeda F, Matsubara T, Ichida F, Hisada K, Nokubi T, Yamaguchi A, Yoneda T. CCAAT/enhancer binding protein b?isoform, LIP, regulates commitment of osteoblasts and adipocytes. Mol Cell Biol 25: 1971-1975, 2005
34.	Yoneda T, Hiraga T. Crosstalk between cancer cells and bone microenvironment in bone metastasis. Biochem Biophys Res Commun 328: 679-687, 2005
35.	Hiraga T, Myoui A, Choi ME, Yoshikawa H, Yoneda T. Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor b enhances bone metastases in breast cancer. Cancer Res 66: 2067-2073, 2006
36.	Ikeda F, Nishimura R, Matsubara T, Hata K, Reddy SV, Yoneda T. Activation of NFAT signal in vivo leads to osteopenia associated with increased osteoclastogenesis and bone resorbing activity. J Immunol 177: 2384-2390, 2006
37.	Nagae M, Hiraga T, Wakabayashi H, Wang L, Iwata K, Yoneda T. Osteoclasts play a part in pain due to the inflammation adjacent to bone. Bone 39: 1107-1115, 2006
38.	Ohno H, Kubo K, Murooka H, Kobayashi Y, Nishitoba T, Shibuya M, Yoneda T, Isoe T. A c-Fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther 5: 2634-2643, 2006
39.	Bowden ET, Onikoyi E, Slack R, Myoui A, Yoneda T, Yamada KM, Mueller SC. Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp Cell Res 312: 1240-1253, 2006
40.	Heyn C, Ronald JA, Ramadan SS, Snir JA, Barry AM, MacKenzie LT, Mikulis DJ, Palmieri D, Bronder JL, Steeg PS, Yoneda T, MacDonald IC, Chambers AF, Rutt BK, Foster PJ. In vivo MRI of cancer cell fate at the single cell level in a mouse model of breast cancer metastasis to the brain. Magnetic Resonance Med 56: 1001-1010, 2006
41.	Palmieri D, Bronder JL, Herring JM, Yoneda T, Weil RJ, Stark AM, Kurek R, Vega-Valle E, Feigenbaum L, Halverson D, Vortmeyer AO, Steinberg SM, Aldape K, Steeg PS. Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain. Cancer Res 67: 4190-4198, 2007
42.	Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark RA, Yoneda T, Abboud HE. NAD(P)H oxidases regulate HIF-2 protein expression. J Biol Chem 282: 8019-8026, 2007
43.	Hiraga T, Kizaka-Kondoh S, Hirota K, Yoneda T. Hypoxia and HIF-1 expression enhance osteolytic bone metastases of breast cancer. Cancer Res 67: 4157-4163, 2007
44.	Shimoyama A, Wada M, Ikeda F, Hata K, Matsubara T, Nifuji A, Noda M, Amano K, Yamaguchi A, Nishimura R, Yoneda T. Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function. Mol Biol Cell 18: 2411-2418, 2007
45.	Hayashibara T, Hiraga T, Ooshima T, Yoneda T. Phosphate deprivation inhibits osteoclast differentiation and function. J Bone Miner Res 22:1743-1751, 2007
46.	Muramatsu S, Wakabayashi M, Ohno T, Ooishi R, Sugahara T, Shiojiri S, Suzuki Y, Sugano S, Nishimura R, Yoneda T, Matsuda A. Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation. J Biol Chem 282:32158-32167, 2007

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