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CURRICULUM VITAE |
NAME
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Cun-Yu Wang D.D.S., Ph.D |
| EDUCATION |
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| 1980-1985 |
Stomatology, Nanjing Medical University |
| 1985-1989 |
Oral Medicine, Perking University |
| 1990-1995 |
Immunology, Forsyth Institute |
1995-1998
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Genet. Mol. Biol., UNC at Chapel Hill |
| POSITIONS |
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| 1990-1993 |
Postdoctoral Fellow, Department of Immunology, Forsyth Institute, Harvard School of Dental Medicine, Mentor: Phil Stashenko |
| 1994-1995 |
Postdoctoral Fellow, Department of Cytokine Biology, Forsyth Institute, Harvard School of Dental Medicine, Mentor: Phil Stashenko |
| 1995-1997 |
Resident, Department of Endodotics, School of Dentistry, UNC at Chapel Hill |
| 1995-1998 |
PhD candidates, Curriculum in Molecular Biology and Genetics, School of Medicine, Mentor: Albert S. Baldwin |
| 1999-2004 |
Associate Professor, Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan |
| 2004-2007 |
Professor, Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan |
2007-Present
|
Professor and Chair, Division of Oral Biology and Medicine, School of Dentistry, UCLA |
| HONORS AND AWARDS |
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| 1995-1998 |
Dentist Scientist Award (NIDR, NIH) |
| 1999 |
Distinguished Science Award-Young Investigator Award, International Association for Dental Research |
| 2003 |
William J. Gies Award for Biological Research, American Association for Dental Research |
| 2004 |
Richard H. Kingery Endowed Collegiate Professor of Dentistry, University of Michigan |
| 2006 |
MERIT Award, NIH/NIDCR |
| SELECTED PEER-REVIEWED PUBLICATIONS |
· Wang, C.-Y., Mayo, M..W., and Baldwin, A.S. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kB. Science. 274: 784-787. One of ten discoveries in 1996 cited by Science
· Mayo, M.M., Wang, C.-Y., Cogswell, P.C., Rogers-Graham, K.S., Lowe, S.W., Der, C.J., and Baldwin, A.S. 1997. Requirement of NF-*B activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science, 278: 1812-1815.
· Wang, C.Y.,* Mayo, M.M., and Baldwin, A.S*. 1998. Mechanism for cell resistance to TNF?: NF-kB activates TRAF1 and 2 and c-IAP1 and 2 to suppress caspase-8-initiated apoptosis. Science 281: 1680-1683. *corresponding authors. The “hot” paper listed by Scientist.
· Wang, C.-Y., Cusack, J. Liu, R., and Baldwin, A.S. 1999. Control of inducible chemoresistance: enhanced anti-tumor therapy via increased apoptosis through inhibition of NF-kB. Nature Medicine. 5: 412-417.
· Mayo, M.W., Wang, C.-Y., Drouin, S.S., Madrid, L.V., Marshall, A.F., Reed, J.C., Weissman, B.E., and Baldwin, A.S. WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene. EMBO J. 18: 3920-3935.
· Wang, C.-Y.*, Guttridge, D.C., Mayo, M.W., and Baldwin, A.S. 1999. NF-kB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol. Cell. Biol. 19: 5923-5929. Corresponding author
· Guttridge, D.C., Mayo, M. W. Madrid, L.V., Wang, C.-Y., and Baldwin, A.S. 2000. NF-?B activation induces the loss of MyoD mRNA: implications for cytokine-induced skeletal muscle dysfunction and cachexia. Science. 289: 2363-2366.
· Chen, S. Guttridge, D.C., You, Z., Zhang, Z., Fribley, A., Kitajewski, J. Wang, C.-Y. 2001. Wnt-1 signaling inhibits apoptosis by activating ?-catenin/Tcf-mediated transcription. J. Cell. Biol. 152: 87-96. Featured by Journal Editorial.
· You, Z., Ouyang, H. Saims, D., and Wang, C.-Y. 2001. Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses TNF-mediated apoptosis by inhibiting caspase-8 activity. J. Biol. Chem. 276: 26398-26404.
· Shi, S., Gronthos, S., Chen, S., Counter, C., Robley, P.G., and Wang, C.-Y. 2002. Potentiation of bone forming capacity of human post-natal bone marrow stromal stem cells in vivo by telomerase expression. Nature Biotech. 20:587-591.
· You, Z., S. Chen, D. Saims, Z. Zhang, K. Guan, O, Macdougall, G. Evan, M. Brown, J. Kitajewiski, and Wang C.-Y.. 2002. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J. Cell Biol. 157:429-440. Featured by Journal editorial.
· Zeng, Q., McCauley, L.K., and Wang, C.-Y. 2002. Hepatocyte growth factor inhibits anoikis by induction of AP-1-dependent cyclooxygenase-2: implication in head and neck squamous cell carcinoma progression. J. Biol. Chem. 277: 50137-50142
· You, Z., Madrid, L.V., Saims, D., Sedivy, J., and Wang, C.-Y. 2002. c-Myc sensitizes cells to TNF-mediated apoptosis by inhibiting NF-?B transactivation. J. Biol. Chem. 277:36671-3667.
· Kniazeva, M., Crawford, Q.T., Seiber, M., Wang, C.-Y., and Han, M. Mono methyl branched fatty acids play essential role in C. elegans development. Plos. Biol. 364:149-155.
· Fribley, A.., Zeng, Q., and Wang, C.-Y. 2004. Proteasome inhibitor PS-341 induces apoptosis through induction of ER stress/reactive oxygen species in head and neck squamous cell carcinoma. Mol. Cell Biol. 24:9695-9704.
· Zeng, Q. Li, S., Polverili, P., Nor, J. E., Kitajewski, J., and Wang, C.-Y. 2005. Crosstalk between tumor and
endothelial cells promotes angiogenesis through MAPK activation of Notch. Cancer Cell 8: 13-23. |
| Commented in Preview. |
· Zhang, H., Kim, J., Edwards, C.A., Xu, Z., Taichman, R., and Wang, C.-Y. 2005. Clusterin inhibits apoptosis
by interacting with activated Bax. Nature Cell Biol. 7: 909-915.
· Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q, Bennett, C., Harada, Y.,
Stankunas, K., Wang, C.-Y., He, X., MacDougald, O.A., You, M., Williams, B.O., and Guan, K.L. 2006. TSC2
integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell
growth. Cell 126:955-968.
· Park, B.K., Zhang, H., Zeng, Q., Dai, J., Keller, E., Giordano, T., Gu, K., Shah, V., Pei, L., Zarbo, R.J.,
McCauley, L., Shi, S., Chen, S., and Wang, C.-Y. 2007. NF-?B in breast cancer promotes osteolytic bone
metastasis by inducing osteoclastogenesis via GM-CSF. Nature Med. 13:62-69. Cover story; Highlighted
in News and Views.
· Cude, K., Wang, Y., Choi, H.J., Hsuan, S.L., Zhang, H., Wang, C.Y., and Xia Z. 2007. Regulation of the
G2-M cell cycle progression by the ERK5-NFkappa B signaling pathway. J Cell Biol. 177:253-264.
· Zua, T, Wang, L., Morrison, C., Chang, X., Zhang, H., Li, W., Wang, Y., Liu, X., Chan, M., Liu, J., Park, B.K., Wang, C.-Y., Zheng, P., and Liu, Y. FoxP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 129:1275-1286.
· Chang, J., Sonoyama, W., Wang, Z., Jin, Q., Zhang, C., Krebsbach, P.H., Giannobile, W., Shi, S., and Wang, C.-Y. 2007. Non-canonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J. Biol. Chem. Online. doi:10.1074/jbc.M702391200, 2007.
· Li, J. and Wang, C.-Y. TBL1/TBLR1 and ?-catenin mutually recruited to Wnt target gene promoter for transcription activation and oncogenesis. Nature Cell Biol. In press. |
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