NAME
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Professor Paul T Sharpe
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| ADDRESS |
GKT Dental Institute, Kings College London, Guy's Hospital, London Bridge, London SE1 9RT, UK |
DATE OF BIRTH
PLACE OF BIRTH |
11th December 1955,
Sheffield, UK
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| E DUCATION |
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·Bsc Hons. Biology, University of York, 1977
·PhD Biochemistry, University of Sheffield, 1981
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| E MPLOYMENT |
·Postdoctoral fellow, University of Sheffield 1981-85
· Postdoctoral fellow, Department of Molecular Embryology, IAPGR, Babraham Institute,
Cambridge, UK 1985-1987
·Lecturer/Reader, Department of Cell and Structural Biology, University of Manchester,
Manchester,
UK 1987-1993
·Dickinson Professor of Craniofacial Biology and Head of Department of Craniofacial
Development, Dental School, Guy's Hospital, London 1994-present
·Head of Division of Craniofacial Biology and Biomaterials 1998-2001
· Head of Division of Craniofacial Biology, Microbiology and Orthodontics 2002-present
·Director of Research, Dental Institute, GKT Schools of Medicine and Dentistry, Kings College
London 1998-present
·Founder and Scientific Director of Odontis, tooth tissue engineering university spin-out company.
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| RECENT PUBLICATIONS |
·Mitsiadis T, Chèraud Y, Sharpe PT Fontaine-Pèrus J (2003). Proc. Natl. Acad. Sci. USA. 100,
6541-6545 elopment of teeth in chick embryos following mouse neural crest transplantations
·Mitsiadis T, Angeli I, James C and Sharpe PT. (2003). Development 130, 4451-4460 Role of
Islet1in patterning of murine dentition
·Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M and Sharpe PT (2004).
Developmental Cell, 6, 219-227
· A dual role for Ikka in tooth development
·Tucker AS, Headon D, Courtney J-M, Overbeek P and Sharpe PT (2004), Dev Biol. 268, 185-194
The activation level of the TNF-family receptor, Edar, determines cusp number and tooth number
during tooth development
·Cobourne M, Miletich I and Sharpe PT (2004). Development 131, 2875-2885 Restriction of sonic
hedgehog signalling during early tooth development
·Ohazama A, Modino SAC, Miletich I and Sharpe PT (2004). J. Dent. Res. 83, 518-522. Stem cell-
based tissue engineering of murine teeth
·Haworth K, Healy C, Morgan P and Sharpe PT (2004). Development 131, 4797-4806 Regional
specification of early head ectoderm is regulated by endoderm and prepatterns the orofacial
epithelium.
·Bogani D, Davis J, Kaur K, Mirza G, Willoughby CP, Paudyal A, Haines H, McKeone R, Cadmann
M, Pieles G, Schneider JE,
·Ragoussis J and Arkell R. (2005). Proc. Natl. Acad. Sci. USA 102, 12477-12482. Functional
annotation of human 6p using a region
·Kim B-M, Buchner G, Miletich I, Sharpe PT and Shivdasani RA (2005). Developmental Cell 8,
611-622. The stomach mesenchymal
·transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt
signalling
·Doherty AO, Ruf S, Mulligan C, hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Hernandez
D, Linehan JM, Sharpe PT,
·Brandner S, Bliss TVP, Henderson DJ, Nizetic D, Tybulewicz LJ, Fisher EMC. (2005). Science
309, 2033-2037 An aneuploid mouse strain carrying chromosome 21 with Down syndrome
phenotypes
·Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe PT and Tarabykin V. (2006)
· Satb2 haploinsufficiency phenocopies 2q32-q33 deletions while loss suggests a fundamental
role in the coordination of jaw development. Am. J. Hum. Gen. 79, 668-678
· Seppala M, Depew M, Martinelli D, Chen-ming Fan, Sharpe PT and Cobourne MT (2007)
· Gas1 is a modifier for holoprosencephaly and genticially interacts with sonic hedgehog
· J. Clin. Invest. 117, 1575-1584
H ONOURS AND AWARDS
• Pagets Disease Foundation 1990 Research Award $10000 "Canine Distemper and Pagets
Disease"
• Presented at the 12th Annual meeting of the American Society For Bone and Mineral Research,
Atlanta, USA
• Walter Oberstebrink Award 1993 $10000 for research on transgenic animal models of Paget's
disease
• Presented at the Paget Foundation Workshop, New York, USA
• Gregor Mendal Memorial Medal 2003. The Mendelianum, Brno, Czech Republic
• Distinguished Scientist Award, Craniofacial Biology 2003, International Association for Dental
Research
IADR William J Gies Award for Biomaterials and Bioengineering Research 2006 |
P ATENTS
1. Robertson N, Morton C, Van Camp G, Fransen E, Van de Heyning P , inventors; The Brigham &
Women's Hospital and University of Antwerp assignees. Methods of diagnosis and treatment of
meniere disease.US patent 6,730,475.2006 May 4.
2. Morton CC, Robertson N, inventors; The Brigham & Women's Hospital assignee.Compositions
to detect lesions associated with hearing loss in the cochlear gene, COCH5B2 . US patent
7,030,235. 2006 Apr 18
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