CURRICULUM VITAE
NAME

 J. Silvio Gutkind
EDUCATION  
　1976-1980 Pharmacy Degree (M.Sc.), University of Buenos Aires, Argentina
　1976-1983 Biochemistry Degree (M.Sc.), University of Buenos Aires, Argentina.
　1985 Ph.D. in Pharmacy and Biochemistry, University of Buenos Aires, Argentina
　 Brief Chronology of Employment
　1998-present Chief, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, USA
　1997-present Chief, Cell Growth Regulation Section and Molecular Carcinogenesis Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, USA
　1996-1997 Acting Chief, Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, NIH, Bethesda, USA
　1993-1997 Chief, Molecular Signaling Unit, Laboratory of Cellular Development and Oncology, National Institute of Dental Research, NIH, Bethesda, USA.
　1992-1993 Head, Molecular Signaling Group, Laboratory of Cellular Development and Oncology, National Institute of Dental Research, NIH, Bethesda, USA.
　1989-1992 Visiting Associate, Laboratory of Cellular Development and Oncology, National Institute of Dental Research, NIH, Bethesda, USA.
　1988-1989 Fogarty Visiting Fellow, Laboratory of Cellular Development and Oncology, National Institute of Dental Research, NIH, Bethesda, USA.
　1987-1988 Fogarty Visiting Fellow, NIDR, Guest Researcher at the Laboratory of Cellular and Molecular -Biology, National Cancer Institute, NIH, Bethesda, USA.
　1983-1986


 Research Assistant, Department of Pharmacology, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
HONORS  
　2007 Frank Brook Memorial Lecture, American Pancreatic Association, Chicago, IL
　2006 Elected, Co-chair, Gordon Research Conference, “Phosphorylation & G-Protein Mediated Signaling Networks”, 2008
　2006 Miguel Aleman Lecture, Miguel Aleman Foundation, Mexico DF, Mexico
　2005 NIH Director's Award
　2005 Elliot Osserman Award, Israel Cancer Research Foundation
　2004 International Association of Dental Research (IADR) Distinguished Scientist Award, Oral Medicine and Pathology
　2003 NIH Hispanic Heritage Month Celebration: Hispanic Contributions to Research in the United States, Lecture
　2000 NIDCR Director's Exemplary Service Award
　1999 EEO Special Achievement Award, NIDCR, NIH
　1998 Appointment as member of the Senior Biomedical Research Services (SBRS)
　1997 NIDR Director's Exemplary Service Award
　1996 NIH Merit Award
　1996 Santa Cruz Biotechnology Investigator Award, Recipient Supervisor
　1989 Funds for Young Scientists, Travel Award, Organizing Committee of the 7th International Conference on Protein Phosphorylation, Kobe, Japan
　1986 International Fogarty Fellowship, National Institutes of Health, USA
　1983


 Gold Medal Award and Diploma of Honor, first rank student of the School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
PROFESSIONAL MEMBERSHIPS
　American Association for the Advancement of Science
　American Society of Microbiology
　American Association of Molecular Biology
　International Association for Dental Research
　American Association for Dental Research
　Founder Member, International Academy of Oral Oncology

EDITORIAL RESPONSIBILITIES
　1998-2003 Member, Editorial Board, Journal of Biological Chemistry
　1998-2000 Editor, Book on Signaling Networks and Cell Cycle Control, Humana Press
　2000-2003 Co-Editor, Book on Head and Neck Cancer, Emerging Perspectives, Wiley & Co
　2000-present Member, Editorial Board, Oral Oncology
　2001-present Member, Editorial Board, Biochemistry
　2001-present Member, Editorial Board, Revista de Oncologia, Mexico-Spain
　2002-2003 Co-Editor, Book on Signal Transduction and Human Disease, Wiley & Co
　2002-present Member, Faculty 1000, Reviewing Editor
　2003-2005 Member, Editorial Board, Drug Discovery Today: Disease Mechanisms
　2005-present Member, Editorial Board, Molecular Biology of the Cell
　2006-present Member, Editorial Board, Current BioData Lipid Signalling
PUBLICATION LIST
1. Gutkind J.S. and Enero M.A. Noradrenaline uptake inhibitors counteract the cardiovascular effects of clonidine but not those of guanabenz. Commun. Biol., 1:319-326, 1983.
2. Gutkind J.S. and Enero M.A. Treatment with clorgyline and pargyline differentially decreases clonidine-induced hypotension and bradycardia. Naunyn Schmiedeberg's Arch. Pharmacol., 327:189-192, 1984.
3. Gutkind J.S., Bognar I., and Enero M.A. Pharmacological characterization of guanabenz, clonidine-like anti-hypertensive drug. J. Cardiol. (Argentina), 53:145-147, 1985.
4. Gutkind J.S., Kazanietz M.G., and Enero M.A. Cardiovascular effects of alpha-adrenergic drugs: differences between clonidine and guanabenz. Naunyn Schmiedeberg's Arch. Pharmacol., 332:370-375, 1986.
5. Gutkind J.S. and Enero M.A. Effects of desipramine on the cardiovascular responses to clonidine and guanabenz. Hypertension, 8:184-186, 1986.
6. Kazanietz M.G., Gutkind J.S., and Enero M.A. Interaction between ?2- and ?2-adrenoceptor responses in the vascular system: effect of clenbuterol. Eur. J. Pharmacol., 130:119-124, 1987.
7. Castren E., Kurihara M., Gutkind J.S., and Saavedra J.M. Specific angiotensin II binding sites in the rat stellate and superior cervical ganglion. Brain Research, 422:347-351, 1987.
8. Gutkind J.S. and Enero M.A. Different pharmacological interaction of clonidine and guanabenz with antidepressive drugs. Clin. Exper. Hypertension, A9:1531-1547, 1987.
9. Gutkind J.S., Kurihara M., Castren E., and Saavedra J.M. Atrial natriuretic peptide receptors in sympathetic ganglia: Biochemical response and alterations in genetically hypertensive rats. Biochem. Biophys. Res. Commun., 149:65-72, 1987.
10. Kurihara M., Castren E., Gutkind J.S., and Saavedra J.M. Lower number of atrial natriuretic peptide receptors in thymocytes and spleen cells of spontaneously hypertensive rats. Biochem. Biophys. Res. Commun., 149:1132-1140, 1987.
11. Saito K., Gutkind J.S., and Saavedra J.M. Angiotensin II binding sites in the conduction system of the rat heart. Am. J. Physiol., 253: (Heart Circ. Physiol. 22), H1618-H1622, 1987.
12. Gutkind J.S., Kurihara M., Castren E., and Saavedra J.M. Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats. J. Hypertension, 6:79-84, 1988.
13. Kurihara M., Gutkind J.S., Saavedra J.M. Alteration of atrial natriuretic peptide binding sites in spontaneously hypertensive rats. Am. J. Hypertension, 1:12S-14S, 1988.
14. Kurihara M., Castren E., Gutkind J.S., Saito K., and Saavedra J.M. Characterization of ?-adrenergic receptors in sections from human blood lymphocyte pellets by quantitative auto-radiography. Biological Psychiatry, 23:746-749, 1988.
15. Nazarali A.J., Gutkind J.S., and Saavedra J.M. Regulation of angiotensin II binding sites in discrete rat brain nuclei after water deprivation. Cell. Molec. Neurobiol., 7:447-455, 1988.
16. Gutkind J.S., Castren E., and Saavedra J.M. Decreased angiotensin II binding in the anterior pituitary gland of spontaneously hypertensive rats. Life Science, 43:441-451, 1988.
17. Gutkind J.S., Kurihara M., Castren E., and Saavedra J.M. Autoradiographic quantification of vasoactive intestinal peptide binding sites in sections from human blood lymphocytes pellets. Neuropsychopharmacol., 1:251-255, 1988.
18. Gutkind J.S., Kurihara M., and Saavedra J.M. Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats. Am. J. Physiol., 255: (Heart Circ. Physiol. 24), H646-H650, 1988.
19. Castren E., Kurihara M., Gutkind J.S., and Saavedra J.M. Atrial natriuretic peptide receptors in thymus and spleen of young spontaneously hypertensive rats. In Advances in Atrial Peptide Research. ASH Symposium Series volume II, 243-247, 1988.
20. Gutkind J.S., Kurihara M., Castren E., and Saavedra J.M. Atrial natriuretic peptide receptors in rat sympathetic ganglia: alterations in genetically hypertensive rats. In Advances in Atrial Peptide Research, ASH Symposium Series volume II, 261-265, 1988.
21. Nazarali A.J., Gutkind J.S., Correa F.M.A., and Saavedra J.M. Effect of chronic administration of the converting enzyme inhibitor enalapril (MK 421) on brain atrial natriuretic peptide receptors in Wistar-Kyoto and spontaneously hypertensive rats. Brain Research, 475:134-140, 1988.
22. Gutkind J.S., Kazanietz M.G., Armando I., Puyo A., and Enero M.A. Pressor response induced by clenbuterol treatment in immobilized normotensive rats. J. Cardiovasc. Pharmacol., 13:793-798, 1989.
23. Kazanietz M.G., Gutkind J.S., Puyo A., Armando I., and Enero, M.A. Further evidence for interaction between vasodilators beta-2-adrenoceptor and vasoconstriction-alpha-2-adrenoceptor mediated responses in maintaining vascular tone in anesthetized rats. J. Cardiov. Pharmacol., 14:874-880, 1989.
24. Nazarali A.J., Gutkind J.S., Correa F.M.A., and Saavedra J.M. Selective decrease of angiotensin II receptors in the subfornical organ of spontaneously hypertensive rats after chronic treatment with a converting enzyme inhibitor. Am. J. Physiol., 256:H1609-H1614, 1989.
25. Nazarali A.J., Gutkind J.S., and Saavedra J.M. Calibration of [125I]-polymer standards with [125I]-brain paste standards for use in quantitative receptor autoradiography. J. Neurosc. Methods, 30:247-253, 1989.
26. Sugita K., Gutkind J.S., Katamine S., and Robbins K.C. The actin domain of Gardner-Rasheed feline sarcoma virus inhibits kinase and transforming activities. J. Virology, 63:1715-1720, 1989.
27. Notario V., Gutkind J.S., Imaizumi M., Katamine S., and Robbins K.C. Expression of the fgr proto-oncogene product as a function of myelomonocytic cell maturation. J. Cell Biol., 109:3129-3136, 1989.
28. Gutkind J.S. and Robbins K.C.: Mobilization of the c-fgr protein-tyrosine kinase as a consequence of neutrophil activation. Proc. Natl. Acad. of Sci. USA, 86:8783-8787, 1989.
29. Gutkind J.S., Lacal P.M., and Robbins K.C. Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets, Mol. Cell. Biol., 10:3806-3809, 1990.
30. Benhamou M., Gutkind J.S., Robbins K.C., and Siraganian R.P. Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. Proc. Natl. Acad. Sci. USA, 87:5327-5330, 1990.
31. Vukicevic S., Paralkar V.M., Cunningham N.S., Gutkind J.S., and Reddi A.H. Autoradiographic localization of osteogenin binding sites in cartilage and bone during rat embryonic development. Dev. Biol., 140:209-214, 1990.
32. Heidaran M.A., Pierce J.H., Lombardi D., Ruggiero M., Gutkind J.S., Matsui T., and Aaronson S.A. Deletion or substitution within the ? PDGF receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways. Mol. Cell. Biol., 11:134-142, 1991.
33. Yu, J.-C., Heidaran M.A., Pierce J.H., Gutkind J.S., Lombardi D., Ruggiero M., and Aaronson S.A. Tyrosine mutations within the ?PDGF kinase insert domain abrogate receptor-associated PI-3 kinase activity without affecting mitogenic or chemotactic signal transduction. Mol. Cell. Biol., 11:3780-3785, 1991.
34. Gutkind J.S., Link D.C., Katamine S., Lacal P., Miki T., Ley T.J., and Robbins K.C. A novel c-fgr exon utilized in Epstein-Barr virus infected B-lymphocytes but not normal monocytes. Mol. Cell. Biol., 11:1505-1507, 1991.
35. Gusovsky F. and Gutkind J.S.: Selective effect of activation of protein kinase-C isoenzymes on cAMP accumulation. Mol. Pharmacol., 39:124-129, 1991.
36. Gutkind J.S., Novotny E., Brann M.R., and Robbins K.C. Muscarinic acetylcholine receptor subtypes as agonist dependent oncogenes. Proc. Natl. Acad. Sci. USA, 88:4703-4707, 1991.
37. Hermouet S., Merendino J. Jr., Gutkind J.S., and Spiegel A.M. Activating and inactivating mutations of G?i2 have opposite effects on proliferation of NIH 3T3 cells. Proc. Natl. Acad. Sci. USA, 88:10455-10459, 1991.
38. Sartor O., Moriuchi R., Sameshima J., Severino M., Gutkind J.S., and Robbins K.C. Diverse biologic properties imparted by the c-fgr proto-oncogene. J. Biol. Chem., 267:3460-3465, 1992.
39. Volker S., Benhamou M., Gutkind J.S., Robbins K.C., and Siraganian R.P. Fc,RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3): Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis. J. Biol. Chem., 267:5434-5441, 1992.
40. Thompson P.A., Gutkind J.S., Robbins K.C., Ledbetter J.A., and Bolen J.B. Identification of distinct populations of PI-3 kinase following T cell activation. Oncogene, 7:719-725, 1992.
41. Link D.C., Gutkind J.S., Robbins K.C., and Ley T.J. Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter. Oncogene, 7:877-884, 1992.
42. Kalinec G., Nazarali A.J., Hermouet S., Xu N., and Gutkind J.S. Mutated ??subunit of the Gq protein induces malignant transformation in NIH 3T3 cells. Mol. Cell. Biol., 12:4687-4693, 1992.
43 Gutkind J.S. and Robbins K.C. Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src substrate. Biochem. Biophys. Res. Commun., 188:155-161, 1992.
44. Wang L.-M., Keegan A.D., Paul W.E., Heidaran M.A., Gutkind J.S., and Pierce J.H. IL-4 activates a distinct signal transduction cascade from IL-3 in factor dependent myeloid cells. EMBO J., 11:4899-1908, 1992.
45. Stephens E.V., Kalinec G., Brann M.R., and Gutkind J.S. Transforming G protein-coupled receptors transduce potent mitogenic signals in NIH 3T3 cells independent of cAMP-inhibition or conventional protein kinase C. Oncogene, 8:19-26, 1993.
46. Wang L.-M., Keegan A.D., Li W., Lienhard G.E., Pacini S., Gutkind J.S., Myers M.G., Sun X.-J, White M.F., Aaronson S.A., Paul W.E., and Pierce J.H. Common elements in IL-4 and insulin signaling pathways in factor dependent hematopoietic cells. Proc. Natl. Acad. Sci. USA 90:4032-4036, 1993.
47. Xu N., Bradley L., Ambdukar I., and Gutkind J.S. A mutant?? subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells. Proc. Natl. Acad. Sci. USA, 90:6741-6745, 1993.
48. Xu N., McCormick F., and Gutkind J.S. The non-catalytic domain of ras-GAP inhibits transformation induced by G protein coupled receptors. Oncogene, 9:597-602, 1994.
49. Xu N., Voyno-Yasenetskaya T., and Gutkind J.S. Potent transforming activity of the G13? subunit defines a novel family of oncogenes. Biochem. Biophys. Res. Commun., 201:603-609, 1994.
50. Calderon S.N., Izenwasser S., Heller B., Gutkind J.S., Mattson M., Su T.-P., and Newman A.H. Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma1 ligands. J. Med. Chem., 37:2285-2291, 1994.
51. Crespo P., Xu N., Daniotti J.L, Rapp U.R, and Gutkind J.S. Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation: Evidence for a protein kinase C independent pathway. J. Biol Chem., 269:21103-21109, 1994.
52. Crespo P., Xu N., Simonds W.F., and Gutkind J.S. Ras-dependent activation of MAP kinase pathway mediated by G-protein??? subunits. Nature, 369:418-420, 1994.
53. Yu J-C., Gutkind J.S., Mahadevan D., Li W., Meyers K.A., Pierce J.H., and Heidaran M.A. Biological function of PDGF-induced PI-3 kinase activity: Its role in ?PDGF receptor-mediated mitogenic signaling. J. Cell Biol., 127:479-488, 1994.
54. Coso O., Chiariello M., Kalinec G., Kyriakis J., Woodgett J., and Gutkind J.S. Transforming G protein-coupled receptors potently activate JNK (SAPK): evidence for a divergence from the tyrosine-kinase signaling pathway. J. Biol. Chem., 270:5620-5624, 1995.
55. Crespo P., Cachero T.G., Xu N., and Gutkind J.S. Dual effect of ?-adrenergic receptors on MAP kinase: Evidence for a ??-dependent activation and a G?s-cAMP-mediated inhibition. J. Biol. Chem., 270:25259-25265, 1995.
56. Crespo P., Mischak H., and Gutkind J.S. Overexpression of mammalian protein kinase C-??does not affect the growth characteristics of NIH 3T3 cells. Biochem. Biophys. Res. Commun., 213:266-272, 1995.
56. Mahadevan D., Thaki N., Singh J., McPhie P., Zangrilli D., Wang L.-M., Guerrero C., LeVine H., Humblet C., Saldanha J., Gutkind J.S., and Haske T. Structural studies on the PH domains of Dbl, Sos1, IRS-1 and ?ARK1 and their differential binding to G???subunits. Biochemistry J. 34:9111-9117, 1995.
57. Miyamoto S., Teramoto H., Coso O., Gutkind J.S., Burbelo P.D., Akiyama S.K., and Yamada K.M. Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J. Cell. Biol., 131:791-805, 1995.
58. Coso O., Chiariello M., Yu J.-C., Crespo P., Teramoto, H., Xu N., Miki T., and Gutkind J.S. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK (SAPK) signaling pathway. Cell, 81:1137-1148, 1995.
59. Coso O.A., Teramoto H., Simonds W.F., and Gutkind J.S. Signaling from G protein-coupled receptors to JNK/SPK involves ?? subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J. Biol. Chem., 271:3963-3966, 1996.
60 Xu N., Coso O.A., Mahadevan D., De Blasi A., Goldsmith P.K., Simonds W.F., and Gutkind J.S. The PH domain of Ras-GAP is sufficient for in vitro binding to ?? subunits of heterotrimeric G proteins. Cell. Mol. Neurobiol., 16:51-59, 1996.
61. Cuvillier O., Pirianov G., Kleuser B., Vanek P.G., Coso O.A., Gutkind J.S., and Spiegel S. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature, 381:800- 803, 1996.
62. Zhang S., Coso O.A., Collins R., Gutkind J.S., and Simonds W.F. A carboxyl-terminal mutant of the G-protein ? subunit deficient in the activation of phospholipase C-?. J. Biol. Chem., 271:20208-20211, 1996.
63. Kieser A., Adler H.S., Seitz T., Crespo P., Gutkind J.S., Kolch W., and Mischak H. Protein Kinase C? inhibits cellular transformation by upregulating jun-B and egr-1 expression. Genes and Development, 10:1455-1466, 1996.
64. Crespo P., Bustelo X.R., Aaronson D.S., Coso O.A., Lopez-Barahona M., Barbacid M., and Gutkind J.S. Rac-1 dependent stimulation of the JNK/SAPK pathway by Vav. Oncogene, 13:455-460, 1996.
65. Sundaresan M., Yu Z.-X., Ferrans V.J., Sulciner D.J., Gutkind J.S., Irani K., Goldschmidt-Clermont P.J., and Finkel T. Regulation of Reactive oxygen species generation in fibroblast by Rac1. Biochem. J., 318:379-382, 1996.
66. Calderon S.N., Bertha C.M., Gutkind J.S., Xu H., Partilla J.S., Rothman R.B., and Rice K. C. Probes for Narcotic receptor mediated phenomena. Synthesis and characterization of optically pure [3H](+)-4-[(?R)-? -((2S,5R)-4-Propyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,Ndiethylbenzamide, [3H]SNC121, a novel high affinity and selective ligand for delta opioid receptors. J. Labelled Comp. Radiopharm. 38:347-350, 1996.
67. Teramoto H., Crespo P., Coso O.A., Igishi T., Xu N., and Gutkind J.S. The small GTP-binding protein Rho activates JNK/SAPK in human kidney 293T cells: Evidence for a Pak-independent signaling pathway. J. Biol. Chem., 271:25731-25734, 1996.
68. Teramoto H., Coso O.A., Miyata H., Igishi T., and Gutkind J.S. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the JNK/SAPK pathway: A role for MLK3/PTK1, a novel member of the mixed-lineage kinase family. J. Biol. Chem., 271:27225-27228, 1996.
69. Zhang S., Coso O.A., Lee C., Gutkind J.S., and Simonds W.F. Selective activation of effector pathways by brain-specific G protein ?5. J. Biol. Chem., 271:33575-33579, 1996.
70. Miyamoto S., Teramoto H., Gutkind J.S., and Yamada K.M. Integrins can synergize with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors. J. Cell Biol., 135:1633-1642, 1996.
71. Herrera L., Hinrichs M.V., Frías J., Gutkind J.S., and Olate J. Dual transduction signaling by a xenopus muscarinic receptor: Adenylyl cyclase inhibition and MAPK activation. J. Cell. Biochem., 64:1-8, 1997.
72. Lopez-Ilasaca M., Crespo P., Pellici P.G., Gutkind J.S.*, and Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase ?. Science, 275:394-397, 1997.
73. Gordeladze J.O., Hovik K.E., Merendino J.J., Hermouet S., Gutkind J.S., and Accili D. Effect of activating and inactivating mutations of Gs- and Gi2-alpha protein subunits on growth and differentiation of 3T3-L1 preadipocytes. J. Cell. Biochem., 64:242-257, 1997.
74. Crespo P., Schuebel K.E., Ostrom A.A., Gutkind J.S., and Bustelo X.R. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature, 385:169-172, 1997.
75. Gutkind J.S., Crespo P., Xu N., Teramoto H., and Coso O.A. The pathway connecting m2 receptors to the nucleus involves small GTP-binding proteins acting on divergent MAP kinase cascades. Life Sci., 60:999-1006, 1997.
76. Teramoto H., Salem P., Robbins K.C., Bustelo X., and Gutkind J.S. Tyrosine phosphorylation of the vav proto-oncogene product links Fc?RI to the Rac1-JNK pathway. J. Biol. Chem., 272:10751-10755, 1997.
77. Lopez-Ilasaca M., Li W., Uren A., Yu J.-C., Kazlauskas A., Gutkind J.S., and Heidaran M.A. Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF-? receptors. Biochem. Biophys. Res. Commun., 232:273-277, 1997.
78. Buckbinder L., Velasco-Miguel S., Xu N., Chen Y., Talbott R., Gelbert L., Gao J., Seizinger B.R., Gutkind J.S., and Kley N. Inhibition of G protein-mediated activation of the MAP kinase pathway by a novel target of the p53 tumor suppressor. Proc. Natl. Acad Sci. U.S.A., 94:7868-7872, 1997.
79. Coso O.A., Montaner S., Fromm C., Teramoto H., Prywes R., Lacal J.C. and Gutkind J.S. Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor: evidence for a Novel JNK-independent pathway. J. Biol. Chem., 272:20691-20697, 1997.
80. Uren A., Jakus J., Font de Mora J., Yeudall A., Santos E., Gutkind J.S., and Heidaran M.A. Carboxy-terminal domain of p27Kip1 activates cdc2. J. Biol. Chem., 272:2669-2672, 1997.
81. Fromm C., Coso O.A., Montaner S., Xu N., and Gutkind J.S. The small GTP-binding protein Rho links G protein-coupled receptors and G?12 to the serum response element and to cellular transformation. Proc. Natl. Acad. Sci. U.S.A., 94:10098-10103, 1997.
82. Jin D.-Y, Teramoto H., Giam L.-Z., Chun R.F., Gutkind J.S., and Jeang K.-T. A human suppressor of JNK activation by TNF?. J. Biol. Chem., 272:25816-25823, 1997.
83. Liu J.L, Blakesley V.A., Gutkind J.S., and Le Roith D. The constitutively active mutant of G?13 transforms mouse fibroblast cells deficient in insulin-growth factor-I receptor. J. Biol. Chem., 272:29438-29441, 1997.
84. Bustelo X.R., Crespo P., Lopez-Barahona M., Gutkind J.S., and Barbacid M. Cbl-b, a member of the sli-1/c-cbl protein family inhibits Vav-mediated c-Jun N-terminal kinase activation. Oncogene, 15:2511-2520, 1997.
85. Alimandi M., Heidaran M.A., Gutkind J.S., Zhang J., Ellmore N., Kazalauskas V.M., Pierce J.H., and Li Q. PLC-??activation is required for PDGF-?R-mediated mitogenesis and monocytic differentiation in myeloid progenitor cells. Oncogene, 15:585-593, 1997.
86. Bais C., Santomasso B., Coso O.A., Arvanitakis L., Raaka E., Gutkind J.S., Asch A., Cesarman E., Gershengorn M.C., and Mesri E. Kaposi's sarcoma associated herpesvirus G protein-coupled receptor is a viral oncogene and angiogenesis activator. Nature, 391:86-89, 1998.
87. Lopez-Ilasaca M., Gutkind J.S., and Wetzker R. Phosphoinositide 3-kinase ? is a mediator of G??-dependent Jun kinase activation. J. Biol. Chem., 273:2505-2508, 1998.
88. Jones T.L.Z. and Gutkind J.S. G?12 requires acylation for its transforming activity. Biochemistry, 37:3196-3202, 1998.
89. Igishi T. and Gutkind J.S. Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors. Biochem. Biophys. Res. Commun., 244:5-10, 1998.
90. Rubino D., Driggers P., Arbit D., Kemp L., Miller B., Coso O., Pagliai K., Gray K., Gutkind J.S. and Segars J. Characterization of Brx, a novel DBL family member that modulates estrogen receptor action. Oncogene, 16:2513-2526, 1998.
91. Chiariello M., Visconti R., Carlomagno F., Melillo R.M., Bucci C., de Franciscis V., Fox G.M., Jing S., Coso O.A., Gutkind J.S., Fusco A., and Santoro M. Signaling of the Ret receptor tyrosine kinase through the JNK: evidence for a divergence of the ERKs and JNKs pathways induced by Ret. Oncogene, 16:2435-2447, 1998.
92. Zohar M., Teramoto H., Katz B.-Z., Yamada K.M., and Gutkind J.S. Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation. Oncogene, 17:991-998, 1998.
93. Murga C., Laguinge L., Wetzker R., Cuadrado A., and Gutkind J.S. Activation of Akt/PKB by G protein-coupled receptors: A role for ? and ???subunits of heterotrimeric G proteins acting through PI3K?. J. Biol. Chem., 273:19080-19085, 1998.
94. Deb T.B., Wong L., Salomon D.S., Zhou G.C., Dixon J.E., Gutkind J.S., Thompson S.A., and Johnson G.R. A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors - A specific role for SHP-2 in MAPK, but not c-jun amino-terminal
kinase activation. J. Biol. Chem., 273:16643-16646, 1998.
95. Crespo P., de Mora J.F., Aaronson D.S., Santos E., and Gutkind J.S.: Transforming G protein-coupled receptors block insulin and ras-induced adipocytic differentiation in 3T3-L1 cells: Evidence for a PKC and MAP kinase independent pathway. Biochem. Biophys. Res. Commun., 245:554-561, 1998.
96. Okubo Y., Blakesley V.A., Stannard B., Gutkind J.S., and Le Roith D. Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase. J. Biol. Chem. ,273:25961-25966, 1998.
97. Winn D.M, Sandberg A.N., Horowitz A.M., Diehl S.R, Gutkind J.S., and Kleinman D.V. Reducing the burden of oral and pharyngeal cancers. J. Calif. Dental Assoc. 26:445-54, 1998.
98. Burstein E.S., Hesterberg D.J., Gutkind J.S., Brann M.R., Currier E.A., and Messier T.L. The ras-related GTPase rac1 regulates a proliferative pathway selectively utilized by G-protein coupled receptors. Oncogene, 17:1617-1623, 1998.
99. Gutkind J.S. The pathway linking G protein-coupled receptors to divergent MAP kinase cascades. J. Biol. Chem., Minireview 273:1839-42, 1998.
100. Gutkind J.S. Cell growth control by G protein-coupled receptors: From signal transduction to signal integration. Oncogene 17:1331-1342, 1998.
101. Patel V., Senderowicz A.M., Pinto D., Ensley J., Igishi T., Sausville E.A., and Gutkind J.S. Flavopiridol, a novel CDK inhibitor, suppresses the growth of squamous cell carcinomas by inducing apoptosis. J. Clin. Invest., 102:1674-1681, 1998.
102. Korn I., Gutkind J.S., Srinivasan N., Blundell T.L., Allende C.C, and Allende J.E. Interactions of protein kinase CK2 subunits. Interactions of protein kinase CK2 subunits. Mol. Cell. Biochem., 191:75-83, 1999.
103. Janulis M., Silberman S., Ambegaokar A., Gutkind J.S., and Schultz R.M. Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts. J. Biol. Chem., 274: 801-813, 1999.
104. Fukuhara S., Murga C., Zohar M., Igishi T., and Gutkind J.S. A novel PDZ-domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J. Biol. Chem., 274:5868-5879, 1999.
105. Heemskerk F., Zorad S., Xu N., Gutkind J.S., and Saavedra J.M. Characterization of AT2 receptor expression in NIH 3T3 fibroblasts. Cell. Mol. Neurobiol., 19:277-288, 1999.
106. Soon L., Flechner L., Gutkind J. S., Wang L.-H., Baserga R., Pierce J. H., and Li W. Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of IRS expression. Mol. Cell. Biol., 19:3816-3824, 1999.
107. Pece S., Chiariello M., Murga C., and Gutkind J.S. Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions - Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. J. Biol. Chem., 274:19347-19351, 1999.
108. Marinissen M.J., Chiariello M., Pallante M., and Gutkind J.S. A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5. Mol. Cell. Biol., 19:4289-4301, 1999.
109. Scita G., Nordstrom J., Carbone R., Tenca P., Giardina G., Gutkind J.S., Bjarneg?rd M., Betsholtz C., Di Fiore P.P. EPS8 and E3B1 Transduce signals from Ras to Rac. Nature 40:290-293, 1999.
110. Igishi T., Fukuhara S., Patel V., Katz B.Z., Yamada K.M., and Gutkind J.S. Divergent signaling pathways link FAK to MAP kinase cascades: A role for paxillin in JNK activation. J. Biol. Chem., 274:30738-30746, 1999.
111. Lerga A., Crespo P., Berciano M., Delgado M.D., Ca?elles M., Calés C., Richard C., Ceballos E., Gutierrez P., Ajenjo N., Gutkind J.S., and Leon J. Regulation of c-Myc and Max in megakaryocytic and monocytic-macrophagic differentiation of K562 cells induced by protein kinase C modifiers: c-Myc is down-regulated but does not inhibit differentiation. Cell Growth Diff., 10:639-654, 1999.
112. Tassi E., Biesova Z., Di Fiore P.P., Gutkind J.S., and Wong W.T. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by EGF. J. Biol. Chem., 274:33287-33295, 1999.
113. Chiang Y.J., Kole H.K., Brown K., Naramura M., Fukuhara S., Hu R.J., Jang I.K., Gutkind J.S., Shevach E., and Gu H. Cbl-b regulates the CD28 dependence of T-cell activation. Nature, 403:216-220, 2000.
114. Shillitoe E.J., May M., Leethanakul C., Patel V., Ensley J.F., Strausberg R.L., and Gutkind J.S. Genome-wide analysis of oral cancer-Early results from the Cancer Genome Anatomy Project. Oral Oncol., 36:8-16, 2000.
115. Chiariello M., Marinissen M.J, and Gutkind J.S. Multiple MAP kinase signaling pathways connect the Cot oncoprotein to the c-jun promoter and to cellular transformation. Mol. Cell. Biol., 20:1747-1758, 2000.
116. Majidi M., Gutkind J.S., and Lichy J.H. Deletion of the COOH terminus converts the ST5 p70 Protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 Cells. J. Biol. Chem., 275:6560-6565, 2000.
117. Katz B.Z., Zohar M., Teramoto H., Matsumoto K., Gutkind J.S., Lin D.C., Lin S., and Yamada K.M. Tensin can induce JNK and p38 activation. Biochem. Biophys. Res. Commun., 272: 717-720, 2000.
118. Pirone D.M., Fukuhara S., Gutkind J.S., Burbelo P.D. SPECs, Small Binding Proteins for Cdc42. J. Biol. Chem., 275:22650-22656, 2000.
119. Sanchez-Prieto R., Rojas J.M., Taya Y., and Gutkind J.S. A role for the p38MAPK pathway in the transcriptional activation of p53 upon genotoxic stress by chemotherapeutic agents. Cancer Res., 60: 2464-2472, 2000.
120. Izevbige E.B.O., Gutkind J.S., and Ray P. E. Angiotensin II and Fibroblast Growth Factor mitogenic signaling pathways in human mesangial cells. Pediatr. Res., 47: 614-621, 2000.
121. Murga C., Fukuhara S., and Gutkind J.S. A novel role for PI3-kinase ? in signaling from G protein-coupled receptors to Akt. J. Biol. Chem., 275: 12069-12073, 2000.
122. Chiariello M., Gomez E., and Gutkind J.S. Regulation of the mammalian G1/S cell cycle restriction point by MAP kinase. J. Biochem., 349:869-876, 2000.
123. Leethanakul C., Patel V., Gillespie J., Shillitoe E., Kellman R.M., Ensley J.E., Limwongse V., Emmert-Buck M.R., Krizman D.V., and Gutkind J.S. Gene expression profiles in squamous cell Carcinomas of the oral cavity: Use of Laser Capture Microdissection for the construction and analysis of stage-specific cDNA libraries. Oral Oncology, 36:474-483, 2000.
124. Leethanakul C., Patel V., Gillespie J., Pallante M., Ensley J.F., Liotta L.A., Emmert-Buck M., and Gutkind J.S. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene, 19:3220-3224, 2000.
125. Izevbigie E.B.O., Gutkind J.S., and Ray P. Isoproterenol inhibits FGFb-induced growth of renal epithelial cells. Ped. Nephrology, 14: 726-734, 2000.
126. Visconti R., Gadina M., Chiariello M., Chen E.H., Stancato L.F., Gutkind J.S., and O'Shea J.J. Importance of MKK6/p38 pathway for IL-12-induced STAT4 serine phosphorylation and transcriptional activity. Blood, 96:1844-1852, 2000.
127. Arozarena I., Aaronson D.S., Sanz V., Ajenjo N., Matallanas D., Teramoto H., Iguishi T., Zabala J.S., Bustelo X.R., Gutkind J.S., and Crespo P. Ras-GRF-induced signaling and cellular transformation requires the participation of the GTPase cdc42. J. Biol. Chem., J. Biol. Chem., 275: 26441-26448, 2000.
128. Hyun T., Yam A., Pece S., Xie X., Zhang J., Miki T., Gutkind J.S., and Li W. Loss of PTEN expression leading to high Akt activation in human multiple myelomas. Blood, 96:3560-3568, 2000.
129. Du Villard J.A., Wicker R., Crespo P., Russo D., Filetti S., Gutkind J.S., Sarasin A., and Suarez H.G. Role of the cAMP and MAPK pathways in the transformation of mouse 3T3 fibroblasts by a TSHR gene constitutively activated by point mutation. Oncogene, 19:4896-4905, 2000.
130. Gutkind J.S. Regulation of Mitogen-Activated Protein Kinase signaling networks by G protein-coupled receptors. Science STKE series, Science's STKE -- Gutkind 2000 (40): 1re, 2000.
131. Fukuhara S. and Gutkind J.S. A new twist for the tumour suppressor hamartin. Nature Cell Biol., 2: E76-E78, 2000.
132. Fukuhara S., Marinissen M.J., Chiariello M., and Gutkind J.S. Signaling from G Protein-coupled receptors to ERK5/BMK 1 involves G?q and G?12/13 families of heterotrimeric G proteins: Evidence for the existence of a novel Ras and Rho-independent pathway. J. Biol. Chem., 275: 21730-21736, 2000.
133. Sodhi A., Montaner S., Patel V., Zohar M., Bais C., Mesri E.A., and Gutkind J.S. The Kaposi's sarcoma associated Herpesvirus G protein-coupled receptor upregulates VEGF expression and secretion through MAPK and p38 pathways acting on HIF-1?. Cancer Research, 60:4873-4880, 2000.
134. Patel V., Ensley J.F., Gutkind J.S., and Yeudall W.A. Induction of apoptosis in head and neck squamous carcinoma cells by ?-irradiation and bleomycin is p53-independent. Internatl. J. Cancer, 88:737-743, 2000.
135. Fukuhara S., Chikumi H., and Gutkind J.S. Leukemia-Associated Rho Guanine Nucleotide Exchange Factor (LARG) links heterotrimeric G proteins of the G12 family to Rho. FEBS Letters, 485:183-188, 2000.
136. Pece S. and Gutkind J.S. Signaling from E-Cadherins to the MAPK pathway by the recruitment and activation of EGF receptors upon cell-cell contact formation. J Biol Chem., 275:41227-41233, 2000.
137. Marinissen M.J., Chiariello M., and Gutkind J.S. Regulation of gene expression by the small GTPase Rho through the ERK6 (p38?) MAP kinase pathway. Genes Dev., 15:535-553, 2001.
138. Marinissen M.J., and Gutkind J.S.: G Protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol. Sci. 22:368-76, 2001.
139. Patel V., Leethanakul C., and Gutkind J.S. New Approaches for the understanding of the molecular basis of oral cancer. Crit. Rev. Oral Med., 12:55-63, 2001.
140. Montaner S., Sodhi A., Pece S., Mesri E.A., and Gutkind J.S. The Kaposi's Sarcoma Associated Herpesvirus G Protein-Coupled Receptor promotes endothelial cell survival through the activation of Akt/PKB. Cancer Res., 61:2641–2648, 2001.
141. Dong F., Gutkind J.S., and Larner A.C. Granulocyte colony-stimulating factor induces erk5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival. J Biol Chem., 276:10811-10816, 2001
142. Yuan P.X., Huang L.D., Jiang Y.M., Gutkind J.S., Manji H.K., and Chen G. The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth. J Biol Chem., 276:31674-31683, 2001.
143. Longenecker K.L., Lewis M.E., Chikumi H., Gutkind J.S., and Derewenda Z.S. Structure of the RGS-like domain from PDZ-RhoGEF linking heterotrimeric G protein-coupled signaling to Rho GTPases. Structure (Cell Press), 9:559-69, 2001.
144. Chiariello M., Marinissen M.J., and Gutkind J.S. Regulation of c-myc expression by PDGF through Rho GTPases. Nature Cell Biol., 3:580-586, 2001.
145. Sodhi A., Montaner S., Miyazaki H., and Gutkind J.S. MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in ras V12 upregulation of VEGF. Biochem Biophys Res Commun., 287:292-300, 2001
146. Knezevic V., Leethanakul C., Bichsel B.E, Worth J.M., Prabhu V.V., Gutkind J.S., Liotta L.A., Munson P.J., Petricoin III E.F., and Krizman D.B. Proteomic profiling of the cancer microenvironment by antibody microarrays. Proteomics, 10:1271-8, 2001.
147. Segrelles C., Ruiz S., Perez P., Murga C., Santos M., Budunova I.V., Martinez J., Larcher F., Slaga T.J., Gutkind J.S., Jorcano J.L., and Paramio J.M. Functional roles of Akt signaling in mouse skin tumorigenseis. Oncogene, 21:53-64. 2002.
148. Murga C., Zohar M., Teramoto H., and Gutkind J.S. Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-?B. Oncogene, 21:207-16, 2002.
149. Sakabe K., Teramoto H., Zohar M., Behbahani B., Miyazaki H., Chikumi H., and Gutkind J.S. Potent transforming activity of the small GTP-binding protein Rit in NIH 3T3 cells: Evidence for a role of a p38? -dependent signaling pathway. FEBS Letters, 511:15-20, 2002
150. Katz B.Z., Miyamoto S., Teramoto H., Zohar M., Krylov D., Vinson C., Gutkind J.S., and Yamada K.M. Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation. Biochim. Biophys. Acta, 1592: 141-152, 2002.
151. Chen H.W., Chen X., Oh S.W., Marinissen M.J., Gutkind J.S., and Hou S.X. Mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family. Genes Dev., 16:388-398, 2002.
152. Orsulic S., Li Y., Soslow R.A., Vitale-Cross L.A., Gutkind J.S., and Varmus H.E. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell, 1: 53-62, 2002.
153. Chikumi H., Fukuhara S., and Gutkind J.S. Regulation of G protein-linked guanine nucleotide exchange for Rho, PDZ-RhoGEF and LARG, by tyrosine phosphorylation: Evidence of a role for FAK. J Biol Chem., 277:12463-12473, 2002.
154. Pece S., and Gutkind J.S. E-cadherin and Hakai: signalling, remodeling or destruction? Nature Cell Biol., 4:E72-4, 2002.
155. Chen H.W., Marinissen M.J., Oh S.W., Chen X., Melnick M., Perrimon N., Gutkind J.S., and Hou S.X. CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Mol Cell Biol., 22:1792-803, 2002.
156. Sanchez-Prieto R., Sanchez-Arevalo V.J., Servitja J.-M., and Gutkind J.S. Regulation of p73 by c-Abl through the p38 MAP kinase pathway. Oncogene, 31:974-979, 2002.
157. Regnauld K.L., Leteurtre E., Gutkind J.S., Gespach C.P., and Emami S. Activation of adenylyl cyclases, regulation of insulin status, and cell survival by G(alpha)olf in pancreatic beta-cells. Am J Physiol., 282:R870-880, 2002.
158. Patel V., Lahusen T., Sy T., Sausville E.A., Gutkind J.S., and Senderowicz A.M. Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest. Cancer Res., 62:1401-1409, 2002.
159. Patel V., Aldridge K., Ensley J.F., Odell E., Boyd A., Jones J., Gutkind J.S., and Yeudall W.A. Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma. Internatl. J Cancer, 99:583-588, 2002.
160. Machado de Sousa S.O., Mesquita R.A, Pinto Jr D.S., and Gutkind J.S. Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma. J. Oral Pathol., 31:78-81, 2002.
161. Choi Y., Zhang J., Murga C., Yu H., Koller E., Monia B.P., Gutkind J.S., and Li W. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells. Oncogene, 21:5289-5300, 2002.
162. Chikumi H., Vazquez-Prado J., Servitja J.-M., Miyazaki H., and Gutkind J.S. Potent activation of RhoA by G?q and Gq-coupled receptors. J Biol Chem., 277:27130-27134, 2002.
163. Perrot V., Vázquez-Prado J., and Gutkind J.S. Plexin B Regulates Rho through the Guanine Nucleotide Exchange Factors LARG and PDZ-RhoGEF. J. Biol. Chem., 277:43115-43120, 2002.
164. Patel V., Lahusen T., Leethanakul C., Igishi T., Kremer M., Quintanilla-Martinez L., Ensley J.F., Sausville E.A., Gutkind J.S., and Senderowicz A.M. Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27KIP1. Clin. Cancer Res. 8:3549-3560, 2002.
165. Aurandt J., Vikis H.G., Gutkind J.S., Ahn N., and Guan K.-L. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc. Natl. Acad. Sci., 99:12085-12090, 2002.
166. Guo Y.S., Cheng J.Z., Jin G.F., Gutkind J.S., Hellmich M.R., and Townsend C.M. Jr. Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of EGF receptor. J. Biol. Chem., 277:48755-48763, 2002.
167. Leethanakul C., Knezevic V., Patel V., Amornphimoltham P., Gillespie J., Shillitoe E.J., Emkoe P., Park M.H., Emmert-Buck M.R., Strausberg R.L., Krizman D.B., and Gutkind J.S. Gene Discovery in Oral Squamous Cell Carcinoma through the Head and Neck Cancer Genome Anatomy Project: Confirmation by Microarray Analysis. Oral Oncology, 39:248-258, 2003.
168. Montaner S., Sodhi A., Molinolo A., Bugge T.H., Sawai E.T., He Y., Li Y., Ray P.E., and Gutkind J.S. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell, 3:23-36, 2003.
169. Servitja J.-M., Masgrau R., Pardo R., Sarri E., von Eichel-Streiber C., Gutkind J.S., and Picatoste F. Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway. Neuropharmacol., 44:171-80, 2003.
170. Nishigaki K., Thompson D., Yugawa T., Rulli K., Hanson C., Cmarik J., Gutkind J.S., Teramoto H., and Ruscetti S. Identification and characterization of a novel Ste-20/GCK-related kinase, PAP kinase (PAPK). J. Biol Chem., 278:13520-13530, 2003.
171. Sriuranpong V., Park J.I., Amornphimoltham P., Patel P., Nelkin B.D., and Gutkind J.S. EGFR-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the IL6/gp130 cytokine system. Cancer Research, 63:2948-2956, 2003.
172. Teramoto H., Malek R.L., Behbahani B., Castellone M.D., Lee N.L., and Gutkind J.S. Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes. Oncogene, 22:2689-2697, 2003.
173. Pedersen T.X., Leethanakul C., Patel V., Mitola D., Lund L.R., Dano K., Johnsen M., Gutkind J.S., and Bugge T.H. Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma. Oncogene, 22:3964-3976, 2003.
174. Servitja J.M., Marinissen M.J., Sodhi A., Bustelo X.R., and Gutkind J.S. Rac1 function is required for Src-induced transformation: Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J. Biol. Chem., 278:34339-34346, 2003.
175. Monje P., Marinissen M.J., and Gutkind J.S. The phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by ERK mediates the transcriptional activation of AP-1 and cellular transformation induced by PDGF. Mol. Cell. Biol., 23:7030-7043, 2003.
176. Marinissen M.J., Servitja J.-M., Offermanns S., Simon M.I., and Gutkind J.S. The thrombin receptor PAR-1 signals through Gq and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation. J. Biol. Chem., 278:46814-46825, 2003.
178. Iavarone C., Catania A., Marinissen M.J., Visconti R., Acunzo M., Tarantino C., Carlomagno M.S., Bruni C.B., Gutkind J.S., and Chiariello M. PDGF controls c-myc expression through a JNK- and AP-1-dependent signaling pathway. J. Biol. Chem., 278: 50024-50030, 2003.
179. Chikumi H., Barac A., Behbahani B., Gao Y., Teramoto H., Zheng Y., and Gutkind J.S. Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential. Oncogene, 23:233-240, 2004.
180. Barac A., Basile J., Vazquez-Prado J., Gao Y., Zheng Y., and Gutkind J.S. Direct interaction of PAK4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. J. Biol. Chem., 279:6182-6189, 2004.
181. Sodhi A., Montaner S., and Gutkind J.S., Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's Sarcomagenesis? Faseb J., 18:422-427, 2004.
182. Sodhi A., Montaner S., Patel V., Román J.G., Li Y., Sausville E.A., Sawai E.T., and Gutkind J.S. Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc. Natl. Acad. Sci., 101:4821-4826, 2004.
183. Amornphimoltham P., Sriuranpong V., Patel V., Benavides F., Conti C.J., Sauk J., Sausville E.A., Molinolo A.A., and Gutkind J.S., Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01, Clin. Cancer Research, 10:4029-37, 2004.
184. Sriuranpong V., Mutirangura A., Gillespie J.W., Patel V., Amornphimoltham P., Molinolo A.A., Kerekhanjanarong V., Supanakorn S., Supiyaphun P., Rangdaeng S., Voravud N., and Gutkind J.S. Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and cDNA microarrays. Clin. Cancer Research, 10:4944-58, 2004.
185. Basile J.R., Barac A., Zhu T., Guan K.-L., and Gutkind J.S. Class IV Semaphorins promote angiogenesis by stimulating Rho-initiated pathways through Plexin-B, Cancer Research, 64:5212-24, 2004.
186. Oliva J.L., Zarich N., Martínez J.R., Castrillo A., Aza?edo M., García-Vargas S., Juarranz A., Boscá L., Gutkind J.S., and Rojas J.M. The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH3T3 cells but not of H-Ras. J. Biol. Chem, 279:33480-91, 2004.
187. Rosenfeldt H., Vazquez-Prado J., and Gutkind J.S. P-Rex2, a novel PI-3-Kinase sensitive Rac exchange factor. FEBS Lett., 572:167-71, 2004.
188. Jeon G.A., Lee J.-S., Patel V., Gutkind J.S., Thorgeirsson S.S., Kim E.C., Amornphimoltham P., and Park M.H. Global gene expression profiles of human head and neck squamous carcinoma cells, Internatl. J. Cancer, 112:249-258, 2004.
189. Kesavapany S., Amin N., Zheng Y.-L., Nijhara R., Jaffe H., Sihag R., Gutkind J.S., Takahashi S., Kulkarni A., Grant P., and Pant H.C. p35/Cdk5 phosphorylation of RasGRF2 mediates Rac-depependent ERK1/2 activity, altering RasGRF2 and MAP1b distribution in neurons. J. Neurosc., 24:4421-4433, 2004.
190. Curino A., Patel V., Schnack-Nielsen B., Iskander A.J., Ensley J.F., Yoo G., Holsinger C., Myers J.N., Shillitoe E.J., Molinolo A.A., Gutkind J.S., and Bugge T.H. Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography. Oral Oncology, 40:1026-1032, 2004.
191. Montaner S., Sodhi A., Servitja J.-M., Ramsdell A.K., Barac A., Sawai E.T., and Gutkind J.S. The small GTPase Rac1 links the Kaposi's Sarcoma Herpesvirus vGPCR to NF?B-mediated transcription and secretion of IL-6 and paracrine neoplasia. Blood, 104:2903-2911, 2004.
192 Vitale-Cross L., Amornphimoltham P., Fisher G., Molinolo A.A., and Gutkind J.S. Conditional expression of K-ras in an epithelial compartment that includes the stem-cells is sufficient to promote squamous cell carcinogenesis. Cancer Res., 64:8804-8807, 2004.
193. Marinissen M.J., Chiariello M., Tanos T., Bernard O., Narumiya S., and Gutkind J.S. The small GTP-binding protein RhoA regulates c-Jun by a ROCK-JNK signaling axis, Mol. Cell, 14:29-41, 2004.
194. Vazquez-Prado J., Miyazaki H., Castellone M.D., Teramoto H., and Gutkind J.S. Chimeric G?i2/G?13 proteins reveal the structural requirements for the binding and activation of RGL-containing Rho GEFs by G?13. J. Biol. Chem., 279:54283-54290, 2004.
195. Sodhi A., Montaner S., and Gutkind J.S. Viral hijacking of G-protein-coupled-receptor signalling networks. Nature Rev. Mol. Cell. Biol., 12:998-1012, 2004.
196. Baker H., Patel V., Molinolo A.A., Myers J.N., El-Naggar A.K., Gutkind J.S., and Hancock W.S. Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass-spectrometry, Oral Oncol., 41:183-199, 2005.
197. Teramoto H., Castellone M.D., Malek R.L., Behbahani B., Letwin N., Gutkind J.S, and Lee N.H. Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12, Oncogene, 24:489-501, 2005.
198. Brantley E., Patel V., Stinson S.F., Trapani V., Hose C.D., Ciolino H.P., Yeh G.C., Gutkind J.S., Sausville E.A., and Loaiza-Perez A.I. The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-kappaB activity in drug-sensitive MCF-7 cells. Anticancer Drugs, 16:137-143, 2005.
199. Dennis P.A., Van Waes C., Gutkind J.S., Kellar K.J, Vinson C., Mukhin A.G., Spitz M.R., Bailey-Wilson J.E., Yeh G.C., Anderson L.M., and Wiest J.S. The Biology of Tobacco and Nicotine: Bench to Bedside. Cancer Epidemiol. Biomarkers Prev., 14:764-767, 2005.
200. Patel V., Ramesh A., Traicoff J.L., Baibakov G., Emmert-Buck M.R., Gutkind J.S., and Knezevic V. Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology. Oral Oncol. 41:503-508, 2005.
201. Tanos T., Marinissen M.J., Coluccio Leskow F., Hochbaum D., Martinetto H., Gutkind J.S., and Coso O.A. Phosphorylation of c-Fos by members of the p38 MAPK family: Role in the AP-1 response to UV. J. Biol. Chem., 280:18842-18852.
202. Marinissen M.J. and Gutkind J.S. Scaffold proteins dictate Rho GTPase-signaling specificity. Trends Biochem Sci., 30:423-426, 2005.
203. Yeudall W.A., Miyazaki H., Ensley J.F, Cardinali M., Gutkind J.S., Patel V. Uncoupling of Epidermal Growth Factor-dependent proliferation and invasion in a model of squamous carcinoma progression. Oral Oncol., 41:698-708, 2005.
204. List K., Szabo R., Molinolo A., Sriuranpong V., Redeye V., Burke B., Murdock T., Nielsen B.S., Gutkind J.S., and Bugge T. H. Deregulated matriptase proteolysis causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes & Dev., 19:1934-1950, 2005.
205. Basile J.R., Afkhami T., and Gutkind J.S. Semaphorin 4D/Plexin-B1 Induces Endothelial Cell Migration through the Activation of PYK2, Src and the PI3K-Akt pathway. Mol. Cell. Biol, 25:6889-6898, 2005.
206. Monje P., Hernández-Losa J., Castellone M.D., Lyons R., and Gutkind J.S. Regulation of the transcriptional activity of c-Fos by ERK: A novel role for the prolyl-isomerase Pin1. J. Biol. Chem., 280:35081-35084, 2005.
207. Amornphimoltham P., Patel V., Sodhi A., Nikitakis N.G., Sauk J.J., Sausville E.A., Molinolo A.A., and Gutkind J.S. mTOR, a molecular target in squamous cell carcinomas of the head and neck. Cancer Research, 65:9953-9961, 2005.
208. Castellone M.D., Teramoto H., Williams B.O., Druey K.M., and Gutkind J.S. Prostaglandin E2 promotes colon cancer cell growth through a novel Gs-axin-?-catenin signaling axis. Science, 310:1504-1510, 2005.
209. Montaner S., Sodhi A., Ramsdell A.K., Martin D., Hu J., Sawai E.T., and Gutkind J.S., The Kaposi's sarcoma associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma. Cancer Research., 66:168-174, 2006.
210. Miyazaki H., Patel V., Wang H., Ensley J.F., Gutkind J.S., Yeudall W.A. Growth factor-sensitive molecular targets identified in primary and metastatic head and neck squamous cell carcinoma using microarray analysis. Oral Oncol., 42:240-256, 2006.
211. Kaur S., Castellone M.D., Bedell V.M., Konar M., Gutkind J.S., and Ramchandran R. Robo4 signaling in endothelial cells implies attraction guidance mechanisms.
J Biol Chem., 281: 1347-1356, 2006.
212. Raimondi R.R., Vitale-Cross L., Amornphimoltham P., Gutkind J.S., and Molinolo A.A. Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter. Amer. J. Pathol., 168:1654-1565, 2006.
213. Kehat I., Heinridh R., Ofer B-I., Miyazaki H., Gutkind J.S., and Aronheim A. Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation.
Cardiovasc Res. 70:543-554, 2006.
214. Gu J., Wu X., Dong Q., Romeo M.J., Lin X., Gutkind J.S., and Berman D.M. A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.
Cancer, 106:2716-2724, 2006.
215. Basile J.R., Castilho R.M., Williams V.P., and Gutkind JS. Semaphorin4D provides a link between anon guidance processes and tumor-induced angiogenesis, Proc. Natl. Acad. Sci. U.S.A. 103:9017-9022, 2006.
216. Gelbard A., Garnett C.T., Abrams S.I., Patel V., Gutkind J.S., Palena C., Tsang K.-Y., Schlom J., and Hodge J.W. Combination chemotherapy and radiation of human squamous cell Carcinoma of the head and neck augments CTL-mediated lysis. Clin. Cancer Res., 12:1897-1905, 2006.
217. Gavard J. and Gutkind J.S. VEGF controls endothelial cell permeability by promoting the ?-arrestin-dependent endocytosis of VE-cadherin. Nature Cell. Biol., 11:1223-1234, 2006.
218. Sodhi A., Chaisuparat R., Hu J., Ramsdell A.K., Manning B.D., Sausville E.A., Sawai E.T., Molinolo A., Gutkind J.S., and Montaner S. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's Sarcoma Associated Herpesvirus G Protein-Coupled Receptor. Cancer Cell, 10:133-143, 2006.
219. Squarize C.H., Castilho R.M., Sriuranpong V., Pinto Jr. D.C., and Gutkind J.S. A molecular cross-talk between the NF?B and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia, 8:733-746, 2006.
220. Rosenfeldt H., Castellone M.D. Randazzo P.A., and Gutkind J.S. Rac inhibits thrombin-induced Rho activation: Evidence of a Pak-dependent GTPase crosstalk. J. Cell Signal. 1:8, 2006.
221. Castellone M.D., Teramoto H., and Gutkind J.S. COX-2 and colorectal cancer: The β-catenin connection. Cancer Research, 66:11085-11088, 2006.
222. Tan W., Martin D., and Gutkind J.S. The G?13-Rho signaling axis is required for SDF-1 induced migration through CXCR4. J. Biol. Chem., 281:39542-39549, 2006.
223. Yu X., Munge B., Patel V., Jensen G., Bhirde A., Gong J.D., Kim S., Gillespie J., Gutkind J.S., Papadimitrakopoulos F., and Rusling J.F. Carbon nanotube amplification strategies for highly sensitive immunosensing of cancer biomarkers in serum and tissue. J. Amer. Chem. Soc., 128:11199-11205, 2006.
224. Teramoto H., Miwa H., Patel V., Letwin N., Castellone M.D., Imai N., Shikami M., Imamura A., Gutkind J.S., Nitta M., Lee N.H. Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray. Clin. Lab. Haematol. 28:262-266, 2006.
225. Sanchez V.M., Crespo A., Gutkind J.S., and Turjanski A.G. Investigation of the catalytic mechanism of farnesyl pyrophosphate synthase by computer simulation. J. Phys. Chem., 110:18052-18057, 2006.
226. Kesavapany S., Pareek T.K., Zheng Y.L., Amin N., Gutkind J.S., Ma W., Kulkarni A.B., Grant P., and Pant H.C. Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras guanine nucleotide releasing factor-1. Neurosignals, 15:157-173, 2006.
227. Dorsam R. and Gutkind J.S. G protein-coupled receptors and cancer. Nature Reviews Cancer, 7:79-94, 2007.
228. Gavard J. and Gutkind J.S. VE-cadherin takes a walk on the wild side. Med Sci (Paris), 23:119-121, 2007.
229. Touge H., Chikumi H., Igishi T., Kurai J., Makino H., Tamura Y., Takata M., Yoneda K., Nakamoto M., Suyama H., Gutkind J.S., and Shimizu E. Diverse activation states of RhoA in human lung cancer cells: Contribution of G protein coupled receptors. Int J Oncol., 30:709-715, 2007.
230. Basile J.R., Holmbeck K., Bugge T.H., and Gutkind J.S. MT1-MMP controls tumor-induced angiogenesis through the release of Semaphorin 4D. J. Biol. Chem., 282:6899-6905, 2007.
231. Castilho R.M., Squarize C.H., Patel V., Millar S.E., Zheng Y., Molinolo A., and Gutkind JS. Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells. Oncogene, 26:5078-5085, 2007.
232. Turjanski A.G., Vaqué J.P., and Gutkind J.S. MAP Kinases and the Control of Nuclear Events. Oncogene, 26:3240-3253, 2007.
233. Montero-Girard G., Vanzulli S.I., Cerliani J.P., Bottino M.C., Bolado J., Vela J., Becu-Villalobos D., Benavides F., Gutkind J.S., Patel V., Molinolo A., and Lanari C. Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment. Breast Cancer Res, 9:R22, 2007.
234. Kupferman M.E., Patel V., Sriuranpong V., Amornphimoltham P., Jasser S.A., Mandal M., Zhou G., Wang J., Coombes K., Multani A., Pathak S., Gutkind J.S., and Myers J.N. Molecular analysis of anoikis resistance in oral cavity squamous cell carcinoma. Oral Oncol., 43:440-454, 2007.
235. Patel V., Rosenfeldt H., Lyons R., Servitja J.-M., Bustelo X.R., Siroff M., and Gutkind J.S. Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR-Vav2 signaling axis involved in cell invasion. Carcinogenesis 28:1145-1152, 2007.
236. Hernandez-Negrete I., Carretero-Ortega J., Rosenfeldt H., Hernandez-Garcia R., Calderon-Salinas J.V., Reyes-Cruz G., Gutkind J.S., and Vazquez-Prado J. P-Rex1 links mTOR signaling to Rac activation and cell migration. J. Biol. Chem., 282:23708-23715, 2007.
237. Honjo Y., Bian Y., Kawakami K., Molinolo A., Longenecker G., Boppana R., Larsson J., Karlsson S., Gutkind J.S., Puri R.K., and Kulkarni A.B. TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell Cycle, 6:1360-1366, 2007.
238. Liu H., Fergusson M.M., Castilho R.M., Liu J., Liu C., Chen J., Malide D., Rovira I.I., Schimel D., Kuo K.J., Gutkind J.S., Hwang P.M., and Finkel T. Augmented Wnt signaling in a mammalian model of accelerated aging. Science, 317:803-806, 2007.
239. Molinolo A.A., Hewitt S., Amornphimoltham P., Keelawat S., Rangdaeng S., Meneses García A., Raimondi A.R., Jufe R., Itoiz M., Gao Y., Saranath D., Kaleebi G.S., Yoo G.H., Leak L., Myers E.M., Shintani S., Wong D., Massey H.D., Yeudall W.A., Lonardo F., Ensley J., and Gutkind J.S. Dissecting the Akt/mTOR signaling network: Emerging results from the Head and Neck Cancer Tissue Array Initiative. Clinical Cancer Research, 13:4964-4973, 2007.
240. Wagenaar-Miller R.A., Engelholm L.H., Gavard J., Yamada S.S., Gutkind J.S., Behrendt N., Bugge T.H., and Holmbeck K. Complementary roles of intracellular and pericellular collagen degradation pathways in vivo. Mol. Cell. Biol., 27:6309-6322, 2007.
241. Kesavapany S., Patel V., Zheng Y.L., Pareek T.K., Bjelogrlic M., Albers W., Amin N., Jaffe H., Gutkind J.S., Strong M.J., Grant P., and Pant H.C. Inhibition of Pin1 Reduces Glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol. Biol. Cell., 18:3645-3655, 2007.
242. Galan-Moya E.M., Hernandez-Losa J., Aceves Luquero C.I., de la Cruz-Morcillo M.A., Ramírez-Castillejo C., Callejas-Valera J.L., Arriaga A., Fernandez Aranburo A, Ramón y Cajal S., Gutkind J.S., and Sánchez-Prieto R. c-Abl activates p38 MAPK independently of its tyrosine kinase activity: implications in Cisplatin based therapy. Int. J. Cancer, in press.
243. Martin M.J., Tanos T.B., Garcia A.B., Martin D., Gutkind J.S., Coso O.A., Marinissen M.J. The Galpha 12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus-G protein coupled receptor to heme oxygenase-1 expression and tumorigenesis. J. Biol. Chem., in press.
244. Basile J.R., Gavard J., Gutkind J.S. Plexin-B1 utilizes RHOA and ROK to promote the integrin-dependent activation of AKT and ERK, and endothelial cell motility. J. Biol. Chem., in press.
245. Martin D., Galisteo R., Ji Y., Montaner S., and Gutkind J.S. A NF-κB gene expression signature contributes to Kaposi's Sarcoma Virus vGPCR-induced direct and paracrine neoplasia. Oncogene, in press.
246. Liu S., Wang H., Currie B.M., Molinolo A., Leung H.J., Moayeri M., Basile J.R., Alfano R.W., Gutkind J.S., Frankel A.E., Bugge T.H., and Leppla S.H.. Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J. Biol. Chem., in press.
247. Gavard J., Patel V., and Gutkind J.S. Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev. Cell, in press.
CHAPTERS
248. Saavedra J.M., Castren E., Gutkind J.S., Kurihara M., and Nazarali A.J. Atrial natriuretic peptide and the autonomous nervous system. In Atrial Natriuretic Peptides. Edited by R. Quirion and W.K. Samson. Boca Raton, Florida: CRC press, Inc., 209-220, 1989.
249. Saavedra J.M., Castren E., Gutkind J.S., and Nazarali A.J. Regulation of brain atrial natriuretic peptide and angiotensin receptors: Quantitative autoradiographic studies. Internatl. Rev. of Neurobiol., 31:257-296, 1989.
250. Gutkind J.S., Lacal P.M., Benhamou M., Siraganian R.P., and Robbins K.C. Evidence for protein-tyrosine kinase involvement in non-proliferative signal transduction. Proc. II Internatl. Symp. on Oncogenes, Spain, 101-132, 1991.
251. Siraganian R.P., Benhamou M., Stephan V., Gutkind J.S., and Robbins K.C. Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. Proc. XIV Internatl. Cong. Allergeology and Clinical Immunology. In Progress in Allergy and Clinical Immunology. Vol. 2. Edited by T. Miyamoto and M. Okuda. Toronto: Hogrefe and Huber, 354-359, 1992.
252. Gutkind J.S., Crespo P., Coso O., Kalinec G., and Xu N. Proliferative signaling through muscarinic acetylcholine receptors: a model for receptors coupled to heterotrimeric G Proteins. In Molecular Mechanisms of Muscarinic Acetylcholine Receptor Function. Edited by Jurgen Wess. R.G Landes, Publisher,103-141, 1995.
253. Gutkind J.S., Crespo P., Coso O., and Xu N. Signaling from heterotrimeric G proteins to MAP kinase involves ?? subunits acting on a ras-dependent pathway. In The Molecular Basis of Cancer and Their Clinical Applications, Spanish Association for Cancer Research. Edited by J. C. Lacal, E. B. Olaetxea and R. Perona, pp. 137-146, 1996.
254. Gutkind J.S. and Vitale-Cross L. The pathway linking small GTP-binding proteins of the Rho Family to cytoskeletal components and novel signaling kinase cascades. Seminars Cell. Dev. Biol., 7:683-690, 1996.
255. Gutkind J.S., Vitale-Cross L., Crespo P., Xu N., Teramoto H., and Coso O.A. The pathway connecting G protein-coupled receptors to the nucleus involves small GTP-binding proteins acting on divergent MAP kinase cascades. In Studies in Stomatology and Craniofacial Biology. Edited by M.M. Cohen, Jr., and B. Baum, IOS Press, pp. 39-57, 1997.
256. Gutkind J.S., Coso O.A., Xu N. G12 and G13 ? subunits of heterotrimeric G proteins: A novel family of oncogenes. In G Proteins, Receptors, and Disease. Edited by A.M. Spiegel. Humana Press, pp. 101-117, 1998.
257. Teramoto H. and Gutkind J.S. The pathway connecting muscarinic acetylcholine receptors to the nucleus involves small GTP-binding proteins. Tanpakushitsu Kakusan Koso, 43:35-41 1998.
258. Gutkind J.S. Signaling from the Membrane to the Nucleus through Divergent MAP Kinase Cascades. In Cell Signal Transduction, Implications for Drug Discovery. IBC Library Series. Edited by Minden S.A. and Guttry P., pp. 39-60, 1998.
259. Winn D.M., Diehl S.R., Horowitz A.M., Gutkind J.S., Sandberg A.N., Kleinman D.V. Scientific progress in understanding oral and pharyngeal cancers. J. Amer. Dental Assoc., 129:713-718, 1998.
260. Chiariello M. and Gutkind J.S. Regulation of MAP Kinases by G Protein-Coupled Receptors. Methods in Enzymology, 345:437-47, 2002.
261. Gutkind J.S. Editor, Book on Signaling Networks and Cell Cycle Control. Humana Press, 2000.
262. Fukuhara S., Marinissen M.J, Chiariello M., and Gutkind J.S. The pathway linking G protein-coupled receptors to the nucleus. In “Signaling Networks and Cell Cycle Control”, Humana Press, Totowa, NJ, JS Gutkind Ed., 83-98, 2000.
263. Todd R., Gutkind J.S., Shillitoe E.J., and Wong D.T. Solid Tumors: Microarray analysis of oral cancers. In “Microarrays and Cancer Research”, Biotechniques Press, Westborough, MA, J.A. Warrington, R. Todd, and D. Wong, Eds., 139-153, 2002.
264. Sodhi A., Montaner S., and Gutkind J.S. Molecular mechanisms of cancer. In Signal Transduction and Human Disease Edited by T. Finkel and J.S. Gutkind. Hoboken, NJ: John Wiley & Sons, pp 71-142, 2003.
265. Patel V., Leethanakul C., Amornphimoltham P., and Gutkind J.S. Squamous carcinomas of the head and neck: Novel genomic approaches. In Head and Neck Cancer Emerging Perspectives. Edited by J.F. Ensley, J.S. Gutkind, J.R. Jacobs, and S.M. Lippman. Academic Press, San Diego, CA. pp. 509-522, 2003.
266. Rosenfeldt H., Marinissen M.J., and Gutkind J.S. G-protein-coupled receptors, cell transformation, and signal fidelity. In Handbook of Cell Signaling, Edited by R.A. Bradshaw and E. A. Dennis. Elsevier Publishing Co., pp 589-599, 2003.
267. Crespo P. and Gutkind J.S. Activation of MAPKs by G Protein-Coupled Receptors. Methods Mol. Biol., 250:203-210, 2004.
268. Vázquez-Prado J., Basile J., and Gutkind J.S. Modular Architecture and Novel Protein-Protein Interactions Regulating RGS-Containing RhoGEFs. Methods in Enzymology, 390:259-285, 2004
269. Teramoto H. and Gutkind J.S. The Mitogen-Activated Protein Kinase family. In Encyclopedia of Biological Chemistry. Edited by W.J. Lennarz and M.D. Lane Elsevier, Oxford, 2:737-742, 2005.
270. Sodhi A. and Gutkind J.S. Endothelial cell transformation by the Kaposi's Sarcoma Herpesvirus. In Encyclopedia of the Microvasculature, Edited by D. Shapro and J.A. Madri. Elsevier Science U.S.A., 147:993-998, 2006.
271. Montaner S. and Gutkind J.S. The vascular endothelium as a target for hemorrhagic fever viruses. In Encyclopedia of the Microvasculature, Edited by D. Shapro and J.A. Madri. Elsevier Science U.S.A., 102:689, 694, 2006.
272. Marinissen M.J. and Gutkind J.S. Regulation of JNK by small GTPases. In The JNK Signaling Pathway. Edited by A. Lin. Landes Bioscience, Georgetown, TX, 2:13-28, 2006.
273. Gavard J. and Gutkind J.S. A Molecular Crosstalk between E-cadherin and EGFR Signaling Networks. in Signaling Network in Can