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CURRICULUM VITAE |
NAME
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David T. Wong |
POSITION TITLE
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Professor |
| EDUCATION |
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| Simon Fraser University, Burnaby, Canada B.Sc. 1979 Biochemistry University of British Columbia, Vancouver, Canada |
| D.M.D. 1981 Dental Medicine |
| Harvard School of Dental Medicine, Boston, MA Certificate 1985 Oral Pathology |
Harvard University, Boston, MA D.M.Sc. 1985 Molecular Biology
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| POSITIONS AND EMPLOYMENT |
| 1986-1991 |
Assistant Professor, Harvard School of Dental Medicine |
| 1990-2001 |
Scientific Staff, Shriner Burns Institute, Boston Unit, Massachusetts General Hospital |
| 1991-2001 |
Consultant in Oral Pathology, Massachusetts General Hospital |
| 1991-2001 |
Associate Professor, Harvard School of Dental Medicine |
| 1993-2001 |
Head, Division of Oral Pathology, Harvard School of Dental Medicine |
| 1995-2001 |
Research Associate, Department of Pathology, Beth Israel-Deaconess Medical Center |
| 2002 |
Professor, UCLA School of Dentistry |
| 2002 |
Director, UCLA Dental Research Institute |
| 2002 |
Member, Jonsson Comprehensive Cancer Center, UCLA |
| 2002 |
Member, Molecular Biology Institute, UCLA |
| 2003-2004 |
Chair, Division of Oral Biology & Medicine, UCLA |
| 2003 |
Co-Director, Head & Neck Oncology Research Program, UCLA Jonsson Comp. Cancer Center |
| 2003 |
Professor, Department of Biomedical Engineering, School of Engineering, UCLA |
| 2003 |
Professor, Div of Head and Neck Surg/Otolaryngology, David Geffen School of Medicine, UCLA |
2005
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Associate Dean of Research, UCLA School of Dentistry |
| HONORS |
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| 1981 Omicron Kappa Upsilon Dental Society |
| 1987-1990 American Cancer Society Cancer Research Scholar Award |
| 1991-1996 USPHS Research Career Development Award |
| 1993 Distinguished Faculty Award, Harvard School of Dental Medicine |
| 2001 Frederick Birnberg Research Award- Columbia University |
| 2003 Distinguished Scientist Award, IADR Oral Medicine and Oral Pathology Research |
| 2004 Distinguished Faculty Award, University of California at Los Angeles |
| 2006 AASS Fellow, American Association for the Advancement of Science |
| 2007 Honorary Membership, American Academy of Oral Medicine |
| 2007 Saliva Researcher of the Year, International Association of Dental Research |
| SELECTED PEER-REVIEWED PUBLICATIONS |
St. John, M, Li, Y, Zhou, X, Denny, P, Ho, C-M, Montemagno, C D, Shi, W, Qi, F, Wu, B, Jordan, R C K, Sinha, U, Park,
N-H, Abemayor, E, and Wong, D T W IL-6 and IL-8: Potential biomarkers for oral cavity and oropharyngeal SCCA.
Arch Otolaryngol Head Neck Surg, 2004, 130: 929-935.
Buajeeb, W, Zhang, X, Ohyam, H, Han, D, Surarita, R, Kim, Y, and Wong, D T. Interaction of the CDK2
associated protein-1, p12DOC-1/CDK2AP1, with its homolog, p14DOC-1R. Biochem Biophys Res Comm,
2004; 315: 998-1003.
Li, Y, Zhou, X, St John, M A, and Wong, D T. RNA Profiling of Cell-free Saliva Using Microarray Technology. J Dent
Res, 2004; 83: 199-203.
Zhou, X, Mok, S, Li, C, Chen, Z, and Wong, D T Concurrent analysis of loss of heterozygosity (LOH) and copy number
abnormality (CNA) for oral premalignancy progression using Affymetrix 10K SNP mapping array. Human Genetics,
2004; 115: 327-330.
Hu, S, Denny, P, Denny, P A, Xie, Y, Loo, J A, Wolinsky, L, Li, Y, McBride, J, Loo, R R, Navazesh, M, and Wong, D T
Differentially expressed proteins markers in human submandibular and sublingual secretions. Int. J. Oncol., 2004; 25:
1423-1430.
Li, Y, St John, M A, Zhou, X, Kim, Y, Sinha, U, Jordan, R C K, Eisele, D, Abemayor, E, Elashoff, D, Park, N H, and
Wong, D T Salivary Transcriptome Diagnostics for Oral Cancer Detection. Clin Cancer Res, 2004; 10: 8442-8450.
Zhou, X, Rao, N P, Cole, S W, Mok, S C, Cheng, Z, and Wong, D T. Progress in concurrent progress in concurrent
analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide
polymorphism arrays. Cancer Genetics & Cytogenetics, 2005, 159: 53-57.
Zhou, X, Cole, S W, Rao, N P, Cheng, Z, Li, Y L, McBride, J, and Wong, D T W. Identification of discrete chromosomal
deletion by binary recursive partitioning of microarray differential expression data. J. Med Genetics, 2004, 42: 416-419.
Kim, Y, McBride, J, Zhang, R, Zhou, X, and Wong, D T. p12CDK2-AP1 mediates DNA damage responses induced by
cisplatin. Oncogene, 2005; 24: 407-418.
Hu, S, Xie, Y, Ramachandran, P, Loo, R R, Li, Y, Loo, J A, and Wong, D T. Large-Scale Identification of Human Oral
Fluid Proteins by Liquid Chromatography-Mass Spectrometry. Proteomics, 2005, 5: 1714-1728.
Kim, Y, Shintani, S, Yohko, K, Zhang, R, and Wong, D T. Cyclin G2 dysregulation in human oral cancer. Cancer
Research., 2004, 64: 8980-8906.
Figueiredo, M L, Kim, Y, St John, M A, and Wong, D T. p12CDK2-AP1 gene therapy strategy inhibits tumor growth in an
in vivo mouse model of head and neck cancer. Clin Cancer Res, 2005; 11: 3939-3948.
Kim, Y, Ohyama, H, Patel, V, Figueiredo, M L, and Wong, D T. Mutation of Cys10 105 inhibits dimerization of p12CDK2-
AP1 and its growth suppressor effect. J Biol Chem, 2005; 280: 23273-23279.
Yang, C Y, Brooks, E, Li, Y, Denny, P, Ho, C M, Qi, F, Shi, W, Wolinsky, L, Wu, B, Wong, D T and
Montemagno, C D Detection of picomolar levels of interleukin-8 in human saliva by SPR. Lab Chip, 2005; 5:
1017-1023.
Zhou, X, Jordan, R C, Li, Y, Huang, B L, and Wong, D T. Frequent allelic imbalances at 8p and 11q22 in oral
and oropharyngeal epithelial dysplastic lesions. Cancer Genet Cytogenet, 2005; 161: 86-89.
Zhou, X, Temam, S, Chen, Z, Ye, H, Mao, L and Wong, D T. Allelic imbalance analysis of oral tongue
squamous cell carcinoma by high-density single nucleotide polymorphism arrays using whole-genome
amplified DNA. Hum Genet, 2005; 118: 504-507.
Li, Y, Elashoff, D, Oh, M, Sinha, U, St John, M A, Zhou, X, Abemayor, E, Wong, D T. Serum Circulating Human
mRNA Profiling and Its Utility for Oral Cancer Detection. Journal Clinical Oncology, 2006; 24: 1754-1760.
Figueiredo, M L, Dyan, S, Kim, Y, McBride, J, Kupper, T and Wong, D T Expression of Cell Cycle Regulator
CDK2-associating protein 1 (p12CDK2AP1) In Transgenic Mice Induces Testicular and Ovarian Atrophy in vivo.
Molecular Reproduction and Development, 2006; 73: 987-99.
Ramachandran, P, Boontheung, P, Xie, Y, Sondej, M, Wong, D T, and Loo, J A L. Identification of N-Linked
Glycoproteins in Human Saliva by Glycoprotein Capture and Mass Spectrometry. J. Proteomic Research,
2006; 5: 1493-1503.
Park, N J, Li, Y, Yu, T, & Wong, D T. Characterization of RNA in Saliva. Clinical Chemistry, 2006, 52: 988-994.
Gu, F, Li, Y, Zhou, X, Wong, D T, Ho, C M, Shi, W, and Qi, F Bacterial 16S RNA/DNA Profiling in the Liquid
Phase of the Saliva. Oral Microbiology and Immunology, 2006: in press.
Kwong, J, Lee, J Y, Wong, K K, Zhou, X, Wong, D T, Lo, K W, Welch, W R, Berkowitz, R S, and Mok, S C Candidate
tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone
hypoacetylation in human epithelial ovarian cancer. Neoplasia, 2006; 8: 268-278.
Zhou, X, Temam, S, Oh, M, Pungpravat, N, Huang, B-L, Mao, L, and Wong, D T. Global expression based
classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma.
Neoplasia, 2006: 8: 925-932.
Park, N J, Yu, T, Nabili, V, Brinkman, B M, Henry, S, Wang, J, and Wong, D T RNAprotect Saliva: An Optimal
Room- Temperature Stabilization Reagent for the Salivary Transcriptome. Clin Chem, 2006; 52: 2303-2304.
Hu, S, Li, Y, Xie, Y, Tjon, K, Loo, R R, Loo, J A L, and Wong, D T. Human Saliva Proteome and Transcriptome.
J. Dent. Res., 2006; 85: 1129-1133.
Park, N J, Zhou, X, Yu, T, Brinkman, A B, Zimmermann, B G, Palanisamy, V, and Wong, D T. Assessing
Salivary mRNA Integrity by cDNA Library Analysis. Arch Oral Biol., 2007: 52: 30-35.
Peng, H, Shintani, S, Kim, Y, and Wong, D T. Loss of p12CDK2-AP1 expression in human oral squamous cell
carcinoma with disrupted transforming growth factor β-Smad signaling pathway Neoplasia, 2007; 8: 1028-36.
Ye, H, Pungpravat, N, Huang, B L, Muzio, L L, Mariggio, M A, Chen, Z, Wong, D T, and Zhou, X Genomic
assessments of the frequent loss of heterozygosity region on 8p21.3 approximately p22 in head and neck
squamous cell carcinoma. Cancer Genetics and Cytogenetics, 2007; 176: 100-106.
Yu, T, Ye, H, Sun, W, Li, K C, Chen, Z, Jacobs, S, Bailey, D K, Wong, D T, and Zhou, X A forward-backward
fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using
high-density single nucleotide polymorphism (SNP) array. BMC Bioinformatics, 2007; 8: 145.
Molinolo, A A, Hewitt, S M, Amornphimoltham, P, Keelawat, S, Rangdaeng, S, Meneses Garcia, A, Raimondi, A
R,, Jufe, R, Itoiz, M, Gao, Y, Saranath, D, Kaleebi, G S, Yoo, G H, Leak, L, Myers, E M, Shintani, S, Wong,
D, Massey, H D, Yeudall, W A, Lonardo, F, Ensley, J, and Gutkind, J S Dissecting the Akt/mammalian target
of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin
Cancer Res, 2007; 13: 4964-4973. |
RESEARCH SUPPORT
Ongoing Research Support |
RO1-DE15970-04 Wong (PI) 05/01/2004-04/30/2009
NIH/NIDCR
Genomics and Proteomics of Oral Precancer Progression
This proposal optimally utilize existing patient resources and emerging genomic, transcriptional and
proteomic tools to harness genomic, transcriptional and proteomic determinants in oral precancer
progression. Role: PI
RO1-DE14857-04 Wong (PI) 07/01/2003-06/30/2008 (NCTE)
NIH/NIDCR
p12CDK2-AP1 in Cell Cycle Control and Oral Carcinogenesis
Characterizing the in vivo role of p12CDK2-AP1 as a negative regulator of CDK2 activities and determining how
this interaction is involved in the TGF-β? antiproliferative pathway. Role: PI
RO1-DE17593-02 Wong (PI) 09/01/2006-08/31/2011
NIH/NIDCR
Salivary Proteomic & Genomic Biomarkers for Primary Sj?gren’s Syndrome
This proposal aims to test the hypothesis that there are signature proteomic and genomic biomarkers in
saliva of primary Sj?gren’s Syndrome patients that can be used for detection, and eventually early
detection, of this disease in a totally non-invasive biofluid, saliva. Role: PI
UO1- DE016275-04 Wong (PI) 09/01/2004-08/31/08
NIH/NIDCR
Human Salivary Proteome
The “Human Salivary Proteome” proposal is a multi-institutional multidisciplinary research consortium
responsive to the NIDCR RFA DE-04-007 aiming to generate a complete catalogue of all salivary secretory
proteins using state of the art, sensitive and high-throughput proteomic technologies. Role: PI
UO1- DE017790-02 Wong (PI) 08/01/2006-07/31/2011
NIH/NIDCR
Oral Fluid NanoSensor Test (OFNASET)
This application includes three highly responsive Specific Aims. Aim 1 will develop the “Oral Fluid
NanoSensor Test (OFNASET)” as a handheld and easy to use instrument (OFNASE-INSTRUMENT) and
associated microfluidic consumables (OFNASE-CARTRIDGE). This integrated system will enable the
simultaneous and rapid detection of multiple salivary protein and nucleic acid targets. Aim 2 will analytically
validate the OFNASET according to diagnostic-industry standards. Aim 3 will preliminarily demonstrate the
clinical utility of OFNASET for clinical oral cancer screening. Role: PI
T32-DE07296-08 Wong (PI) 07/01/2003-06/30/2008
NIH/NIDCR
UCLA Fundamental Clinical Research Training Grant
The objective of this training program is to provide a rigorous training environment for clinician (DDS/DMD,
MD), basic (PhD) and baccalaureate scientists to enable them to pursue academic careers in oral health
research. The mission is to foster novel, mentored research highly relevant to oral health by specific
curriculum aims in three areas: (1) Bioengineering and Bone Biology, (2) Head and Neck Cancer, and (3)
Microbiology and Immunity. Role: Program Director |
| Completed Research Support |
UO1-DE15018-04 Wong (PI) 10/01/2002-09/30/2006
NIH/NIDCR
UCLA Collaborative Oral Fluid Diagnostic Research Center
This proposal integrates micro- and nano-microelectronic mechanical system (MEMS/NEMS) technologies
to oral fluid as the diagnostic medium to monitor the health and/or disease status of individuals. Role: PI
R21/R33 CA 095231 Jordan (PI) 04/01/2002 to 03/31/2007
NIH/NCI
Molecular Predictors of Oral Cancer Development
This proposal aims to optimize quantitative PCR for the analysis of gene expression in routinely processed
oral biopsies and to establish the quantitative requirement for LCM-generated RNA for real-time PCR.
Role: Co-Investigator
Interdisciplinary Cancer Research Grant Wong (PI) 07/01/02 – 06/30/04
Jonsson Comprehensive Cancer Center
Oral Fluid Based Molecular Diagnostics for Head and Neck Cancer. Role: PI
R24 DE015483-01 Wong (PI) 07/01/2003 to 06/30/2004
NIH/NIDCR
Research Infrastructure Improvement for The UCLA SOD
This planning application to improve the research infrastructure for oral health research. Role: PI
R21 CA94216-01 Wong (PI) 02/01/02 - 01/31/04
NIH/ NCI
Molecular Predictors of Oral Premalignancy Progression. Role: PI
PO1 DE12467 Wong (Program Director & PI) 04/01/98 - 03/31/03
NIH/ NIDCR
Cell Cycle Regulators of Oral Cancer
Role: Program Director and PI, Research Project #3: Cell Cycle Biology of doc-1 |
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