2008 International Conference on Frontiers of Dental and Craniofacial Research

CURRICULUM VITAE
NAME	Bruce J. Baum
POSITION TITLE	Chief, GTS, GTTB, NIDCR
EUCATION
1967	History, University of Virginia, Charlottesville
1971	Dentistry, Tufts University, Boston, MA
1974	Biochemistry, Boston University, MA
RESEARCH AND PROFESSIONAL EXPERIENCE
1974-76	Naval Dental Research Officer, Dental Sciences Dept., NNMC, Bethesda, MD
1976-78	Staff Investigator, Pulmonary Branch, NHLBI, NIH, Bethesda, MD
1978-81	Senior Investigator, Lab. of Molecular Aging, NIA, NIH, Baltimore, MD
1982-96	Clinical Director, and Chief, Clinical Investigations and Patient Care Branch, NIDR, NIH, Bethesda, MD
1996-05	Chief, Gene Therapy and Therapeutics Branch, NIDCR, NIH, Bethesda, MD
2005	Chief, Gene Transfer Section, GTTB, NIDCR, NIH, Bethesda, MD
HONORS
1992	Fellow, AAAS
1993	Salivary Research Award, IADR; Samuel Charles Miller Award, American Academy of Oral Medicine
1994	J. Murray Gavel Clinical Research Lectureship, Forsyth Dental Center
1995	Geriatric Oral Research Award, IADR
1996	NIH Senior Biomedical Research Service
1997	Columbia University Birnberg Research Award
1999	Honorary Professorship, Capital University, Beijing, P. R. China
2000	Jack Lewin Epstein Memorial Lectureship, Hebrew University, Jerusalem, Israel; American Dental Association, Norton Ross Award
2001	Leo M. Sreebny Visiting Scholar, SUNY-Stony Brook; Isidore Cabakoff Lectureship, Hebrew University, Jerusalem, Israel
2002	New York University, Distinguished Scientist Award , Tufts University, Alumni Distinguished Service Award; Broegelmann Lecturer, University of Bergen, Norway
2006	J. A. Young Lecture, Federation of Asian & Oceanian Physiological Societies, Seoul, KR
2007	Oral Medicine and Pathology Research Award, IADR
REPRESENTATIVE OTHER ACTIVITIES
1991 - 2002	Editorial Board, Oral Surgery, Oral Medicine, Oral Pathology
1994 - 1996	Special Consultant in Dental Education, Indiana University; Chair-elect, then Chair, Section R (Dentistry) AAAS
1995 - 1997	Member, NIH Committee on Scientific Conduct and Ethics
1996 - Present	Board of Tutors, NIH Clinical Research Training Program; Associate Editor. European Journal of Dental Education
1998 - 2001	Editorial Board, Journal of Dental Research
1999	Chair, Salivary Glands and Saliva Gordon Research Conference
1999 - Present	Senior Editor, Oral Diseases ; Member, Board of Overseers, Tufts University School of Dental Medicine; Chair, Admissions Committee, NIH-Duke Master of Health Sciences in Clinical Research program
1999 - 2000	Member, Scientific Advisory Board, Genteric, Inc., Alameda, CA
2000 -2001	Chair, Section 5.3, DentEdEvolves, Association for Dental Education in Europe
2002 - 2004	Member, Scientific Advisory Board, Dentigenix LLC, Kirkland, WA
2003 - Present	Member, Scientific Advisory Board, Harvard School of Dental Medicine
2006 - Present	Member, NIH Central Tenure Committte

REPRESENTATIVE PUBLICATIONS

Hoque, A.T.M.S., Baccaglini, L. and Baum, B.J. Hydroxychloroquine enhances the endocrine secretion of adenovirus-directed growth hormone from rat submandibular glands in vivo. Human Gene Ther. 12:1333-1342, 2001.

Kok, M.R., Yamano, S., Lodde, B.M., Wang, J., Couwenhoven, R.I., Yakar, S., Voutetakis, A., Leroith, D., Schmidt, M., Afione, S., Pillemer, S.R., Tsutsui, M.T., Tak, P.P., Chiorini, J.A. and Baum, B.J. Local adeno-associated virus-mediated interleukin-10 gene transfer has disease modifying effects in a murine model of Sjogren’s syndrome. Human Gene Ther. 14:1605-1608, 2003.

Li, J., Zheng, C., Zhang, X., Liu, X., Zhang, C., Goldsmith, C.M., Baum, B.J. and Wang, S. Developing a convenient large animal model for gene transfer to salivary glands in vivo. J Gene Med. 6:55-63, 2004.

Voutetakis, A., Kok, M.R., Zheng, C., Bossis, I., Wang, J., Cotrim, A.P., Marracino, N., Goldsmith, C.M., Chiorini, J.A., Loh, Y.P., Nieman, L.K. and Baum, B.J. Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics. Proc Natl Acad Sci USA. 101:3053-3058, 2004.

Baum, B.J., Voutetakis, A. and Wang, J. Salivary glands: novel target sites for gene therapeutics. Trends Mol Med. 10: 585-590, 2004.

Shan, Z., Li, J., Zheng, C., Liu, X., Zhang, C., Goldsmith, C.M., Wellner, R.B., Baum, B.J. and Wang, S.
Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands. Mol Ther. 11: 444-451, 2005.

Wang, J. Cawley, N.X., Voutetakis, A., Rodriguez, Y., Goldsmith, C.M., Nieman, L.K., Hoque, A.T.S.,
Snell, C., Frank, S.J., Loh, Y.P. and Baum, B.J. Partial re-direction of transgenic human growth hormone secretion from rat salivary glands. Hum. Gene Ther. 16: 571-583, 2005.

Wang, J., Voutetakis, A., Papa, M., Rivera, V.M., Clackson, T., Lodde, B.M., Mineshiba, F. and Baum, B.J. Rapamycin control of transgene expression from a single AAV vector in mouse salivary glands. Gene Ther. 13:187-190, 2006.

Zheng, C., Goldsmith, C.M., Mineshiba, F., Chiorini, J.A., Kerr, A., Wenk, M.L., Vallant, M., Irwin, R.D. and Baum,B.J. Toxicity and biodistribution of a first-generation recombinant adenoviral vector encoding aquaporin-1 after retroductal delivery to a single rat submandibular gland. Hum. Gene Ther. 17: 1122-1133, 2006.

Baum, B.J. Inadequate training in the biological sciences and medicine forr dental students: An impending crisis for dentistry. J. Amer. Dent. Assoc. 138: 16-26, 2007.

Voutetakis, A., Zheng, C., Mineshiba, F., Cotrim, A.P., Goldsmith, C.M., Schmidt, M., Afione, S., Roescher, N., Metzger, M., Eckhaus, M.A., Chiorini, J.A., Dunbar, C.E., Donahue, R.E., and Baum, B.J. AAV2-mediated gene transfer to the parotid glands of non-human primates. Hum. Gene Ther. 18:42-150, 2007.

Yan, X., Voutetakis, A., Zheng, C., Hai, B., Zhang, C., Baum, B.J. and Wang, S. Sorting of transgenic secretory proteins in miniature pig parotid glands following adenoviral-mediated gene transfer. J. Gene Med. 2007 Jul 26; [Epub ahead of print].

Cotrim, A.P., Sowers, A., Mitchell, J.B., and Baum, B.J. Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands. Mol Ther. (in press)

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